| Regular Season: Week 1 |
 Vikings |
at |
 Bills |
Sunday, August 31, 1997 |
3:00PM |
MIN 34, BUF 13 |
| Regular Season: Week 2 |
Bills |
at |
 Jets |
Sunday, September 7, 1997 |
3:00PM |
BUF 28, NYJ 22 |
| Regular Season: Week 3 |
Bills |
at |
 Chiefs |
Sunday, September 14, 1997 |
3:00PM |
BUF 16, KC 22 |
| Regular Season: Week 4 |
 Colts |
at |
Bills |
Sunday, September 21, 1997 |
3:00PM |
IND 35, BUF 37 |
| Regular Season: Week 6 |
 Lions |
at |
Bills |
Sunday, October 5, 1997 |
3:00PM |
DET 13, BUF 22 |
| Regular Season: Week 7 |
Bills |
at |
 Patriots |
Sunday, October 12, 1997 |
3:00PM |
BUF 6, NE 33 |
| Regular Season: Week 8 |
Bills |
at |
Colts |
Monday, October 20, 1997 |
3:00PM |
BUF 9, IND 6 |
| Regular Season: Week 9 |
 Broncos |
at |
Bills |
Sunday, October 26, 1997 |
2:00PM |
DEN 23, BUF 20 |
| Regular Season: Week 10 |
 Dolphins |
at |
Bills |
Sunday, November 2, 1997 |
3:00PM |
MIA 6, BUF 9 |
| Regular Season: Week 11 |
Patriots |
at |
Bills |
Sunday, November 9, 1997 |
3:00PM |
NE 31, BUF 10 |
| Regular Season: Week 12 |
Bills |
at |
Dolphins |
Monday, November 17, 1997 |
3:00PM |
BUF 13, MIA 30 |
| Regular Season: Week 13 |
Bills |
at |
 Oilers |
Sunday, November 23, 1997 |
3:00PM |
BUF 14, TEN 31 |
| Regular Season: Week 14 |
Jets |
at |
Bills |
Sunday, November 30, 1997 |
3:00PM |
NYJ 10, BUF 20 |
| Regular Season: Week 15 |
Bills |
at |
 Bears |
Sunday, December 7, 1997 |
3:00PM |
BUF 3, CHI 20 |
| Regular Season: Week 16 |
 Jaguars |
at |
Bills |
Sunday, December 14, 1997 |
3:00PM |
JAC 20, BUF 14 |
| Regular Season: Week 17 |
Bills |
at |
 Packers |
Saturday, December 20, 1997 |
3:00PM |
BUF 21, GB 31 |