| Regular Season: Week 1 |
 Bills |
at |
 Colts |
Sunday, September 12, 1999 |
3:00PM |
BUF 14, IND 31 |
| Regular Season: Week 2 |
 Jets |
at |
Bills |
Sunday, September 19, 1999 |
3:00PM |
NYJ 3, BUF 17 |
| Regular Season: Week 3 |
 Eagles |
at |
Bills |
Sunday, September 26, 1999 |
3:00PM |
PHI 0, BUF 26 |
| Regular Season: Week 4 |
Bills |
at |
 Dolphins |
Monday, October 4, 1999 |
3:00PM |
BUF 23, MIA 18 |
| Regular Season: Week 5 |
 Steelers |
at |
Bills |
Sunday, October 10, 1999 |
3:00PM |
PIT 21, BUF 24 |
| Regular Season: Week 6 |
 Raiders |
at |
Bills |
Sunday, October 17, 1999 |
3:00PM |
OAK 20, BUF 14 |
| Regular Season: Week 7 |
Bills |
at |
 Seahawks |
Sunday, October 24, 1999 |
3:00PM |
BUF 16, SEA 26 |
| Regular Season: Week 8 |
Bills |
at |
 Ravens |
Sunday, October 31, 1999 |
2:00PM |
BUF 13, BAL 10 |
| Regular Season: Week 9 |
Bills |
at |
 Redskins |
Sunday, November 7, 1999 |
3:00PM |
BUF 34, WAS 17 |
| Regular Season: Week 10 |
Dolphins |
at |
Bills |
Sunday, November 14, 1999 |
3:00PM |
MIA 3, BUF 23 |
| Regular Season: Week 11 |
Bills |
at |
Jets |
Sunday, November 21, 1999 |
3:00PM |
BUF 7, NYJ 17 |
| Regular Season: Week 12 |
 Patriots |
at |
Bills |
Sunday, November 28, 1999 |
3:00PM |
NE 7, BUF 17 |
| Regular Season: Week 14 |
 Giants |
at |
Bills |
Sunday, December 12, 1999 |
3:00PM |
NYG 19, BUF 17 |
| Regular Season: Week 15 |
Bills |
at |
 Cardinals |
Sunday, December 19, 1999 |
3:00PM |
BUF 31, ARI 21 |
| Regular Season: Week 16 |
Bills |
at |
Patriots |
Sunday, December 26, 1999 |
3:00PM |
BUF 13, NE 10 |
| Regular Season: Week 17 |
Colts |
at |
Bills |
Sunday, January 2, 2000 |
3:00PM |
IND 6, BUF 31 |
| Wild Card: Week 18 |
Bills |
at |
 Titans |
Saturday, January 8, 2000 |
3:00PM |
BUF 16, TEN 22 |