| Regular Season: Week 1 |
 Titans |
at |
 Bills |
Sunday, September 3, 2000 |
8:20PM |
TEN 13, BUF 16 |
| Regular Season: Week 2 |
 Packers |
at |
Bills |
Sunday, September 10, 2000 |
1:00PM |
GB 18, BUF 27 |
| Regular Season: Week 3 |
Bills |
at |
 Jets |
Sunday, September 17, 2000 |
1:00PM |
BUF 14, NYJ 27 |
| Regular Season: Week 5 |
 Colts |
at |
Bills |
Sunday, October 1, 2000 |
1:00PM |
IND 18, BUF 16 |
| Regular Season: Week 6 |
Bills |
at |
 Dolphins |
Sunday, October 8, 2000 |
1:00PM |
BUF 13, MIA 22 |
| Regular Season: Week 7 |
 Chargers |
at |
Bills |
Sunday, October 15, 2000 |
1:00PM |
SD 24, BUF 27 |
| Regular Season: Week 8 |
Bills |
at |
 Vikings |
Sunday, October 22, 2000 |
1:00PM |
BUF 27, MIN 31 |
| Regular Season: Week 9 |
Jets |
at |
Bills |
Sunday, October 29, 2000 |
1:00PM |
NYJ 20, BUF 23 |
| Regular Season: Week 10 |
Bills |
at |
 Patriots |
Sunday, November 5, 2000 |
1:00PM |
BUF 16, NE 13 |
| Regular Season: Week 11 |
 Bears |
at |
Bills |
Sunday, November 12, 2000 |
1:00PM |
CHI 3, BUF 20 |
| Regular Season: Week 12 |
Bills |
at |
 Chiefs |
Sunday, November 19, 2000 |
1:00PM |
BUF 21, KC 17 |
| Regular Season: Week 13 |
Bills |
at |
 Buccaneers |
Sunday, November 26, 2000 |
1:00PM |
BUF 17, TB 31 |
| Regular Season: Week 14 |
Dolphins |
at |
Bills |
Sunday, December 3, 2000 |
1:00PM |
MIA 33, BUF 6 |
| Regular Season: Week 15 |
Bills |
at |
Colts |
Monday, December 11, 2000 |
9:00PM |
BUF 20, IND 44 |
| Regular Season: Week 16 |
Patriots |
at |
Bills |
Sunday, December 17, 2000 |
1:00PM |
NE 13, BUF 10 |
| Regular Season: Week 17 |
Bills |
at |
 Seahawks |
Saturday, December 23, 2000 |
8:20PM |
BUF 42, SEA 23 |