| Regular Season: Week 1 |
 Texans |
at |
 Bills |
Sunday, September 11, 2005 |
1:00PM |
HOU 7, BUF 22 |
| Regular Season: Week 2 |
Bills |
at |
 Buccaneers |
Sunday, September 18, 2005 |
1:00PM |
BUF 3, TB 19 |
| Regular Season: Week 3 |
 Falcons |
at |
Bills |
Sunday, September 25, 2005 |
1:00PM |
ATL 24, BUF 16 |
| Regular Season: Week 4 |
Bills |
at |
 Saints |
Sunday, October 2, 2005 |
1:00PM |
BUF 7, NO 19 |
| Regular Season: Week 5 |
 Dolphins |
at |
Bills |
Sunday, October 9, 2005 |
1:00PM |
MIA 14, BUF 20 |
| Regular Season: Week 6 |
 Jets |
at |
Bills |
Sunday, October 16, 2005 |
4:15PM |
NYJ 17, BUF 27 |
| Regular Season: Week 7 |
Bills |
at |
 Raiders |
Sunday, October 23, 2005 |
4:15PM |
BUF 17, OAK 38 |
| Regular Season: Week 8 |
Bills |
at |
 Patriots |
Sunday, October 30, 2005 |
8:30PM |
BUF 16, NE 21 |
| Regular Season: Week 10 |
 Chiefs |
at |
Bills |
Sunday, November 13, 2005 |
1:00PM |
KC 3, BUF 14 |
| Regular Season: Week 11 |
Bills |
at |
 Chargers |
Sunday, November 20, 2005 |
4:15PM |
BUF 10, SD 48 |
| Regular Season: Week 12 |
 Panthers |
at |
Bills |
Sunday, November 27, 2005 |
1:00PM |
CAR 13, BUF 9 |
| Regular Season: Week 13 |
Bills |
at |
Dolphins |
Sunday, December 4, 2005 |
1:00PM |
BUF 23, MIA 24 |
| Regular Season: Week 14 |
Patriots |
at |
Bills |
Sunday, December 11, 2005 |
1:00PM |
NE 35, BUF 7 |
| Regular Season: Week 15 |
 Broncos |
at |
Bills |
Saturday, December 17, 2005 |
8:30PM |
DEN 28, BUF 17 |
| Regular Season: Week 16 |
Bills |
at |
 Bengals |
Saturday, December 24, 2005 |
1:00PM |
BUF 37, CIN 27 |
| Regular Season: Week 17 |
Bills |
at |
Jets |
Sunday, January 1, 2006 |
1:00PM |
BUF 26, NYJ 30 |