| Regular Season: Week 1 |
 Seahawks |
at |
 Bills |
Sunday, September 7, 2008 |
1:00PM |
SEA 10, BUF 34 |
| Regular Season: Week 2 |
Bills |
at |
 Jaguars |
Sunday, September 14, 2008 |
1:00PM |
BUF 20, JAC 16 |
| Regular Season: Week 3 |
 Raiders |
at |
Bills |
Sunday, September 21, 2008 |
1:00PM |
OAK 23, BUF 24 |
| Regular Season: Week 4 |
Bills |
at |
 Rams |
Sunday, September 28, 2008 |
4:05PM |
BUF 31, STL 14 |
| Regular Season: Week 5 |
Bills |
at |
 Cardinals |
Sunday, October 5, 2008 |
4:15PM |
BUF 17, ARI 41 |
| Regular Season: Week 7 |
 Chargers |
at |
Bills |
Sunday, October 19, 2008 |
1:00PM |
SD 14, BUF 23 |
| Regular Season: Week 8 |
Bills |
at |
 Dolphins |
Sunday, October 26, 2008 |
1:00PM |
BUF 16, MIA 25 |
| Regular Season: Week 9 |
 Jets |
at |
Bills |
Sunday, November 2, 2008 |
1:00PM |
NYJ 26, BUF 17 |
| Regular Season: Week 10 |
Bills |
at |
 Patriots |
Sunday, November 9, 2008 |
1:00PM |
BUF 10, NE 20 |
| Regular Season: Week 11 |
 Browns |
at |
Bills |
Monday, November 17, 2008 |
8:30PM |
CLE 29, BUF 27 |
| Regular Season: Week 12 |
Bills |
at |
 Chiefs |
Sunday, November 23, 2008 |
1:00PM |
BUF 54, KC 31 |
| Regular Season: Week 13 |
 49ers |
at |
Bills |
Sunday, November 30, 2008 |
1:00PM |
SF 10, BUF 3 |
| Regular Season: Week 14 |
Dolphins |
at |
Bills |
Sunday, December 7, 2008 |
4:05PM |
MIA 16, BUF 3 |
| Regular Season: Week 15 |
Bills |
at |
Jets |
Sunday, December 14, 2008 |
1:00PM |
BUF 27, NYJ 31 |
| Regular Season: Week 16 |
Bills |
at |
 Broncos |
Sunday, December 21, 2008 |
4:05PM |
BUF 30, DEN 23 |
| Regular Season: Week 17 |
Patriots |
at |
Bills |
Sunday, December 28, 2008 |
1:00PM |
NE 13, BUF 0 |