| Regular Season: Week 1 |
 Bills |
at |
 Patriots |
Monday, September 14, 2009 |
7:00PM |
BUF 24, NE 25 |
| Regular Season: Week 2 |
 Buccaneers |
at |
Bills |
Sunday, September 20, 2009 |
4:05PM |
TB 20, BUF 33 |
| Regular Season: Week 3 |
 Saints |
at |
Bills |
Sunday, September 27, 2009 |
4:05PM |
NO 27, BUF 7 |
| Regular Season: Week 4 |
Bills |
at |
 Dolphins |
Sunday, October 4, 2009 |
4:05PM |
BUF 10, MIA 38 |
| Regular Season: Week 5 |
 Browns |
at |
Bills |
Sunday, October 11, 2009 |
1:00PM |
CLE 6, BUF 3 |
| Regular Season: Week 6 |
Bills |
at |
 Jets |
Sunday, October 18, 2009 |
4:15PM |
BUF 16, NYJ 13 |
| Regular Season: Week 7 |
Bills |
at |
 Panthers |
Sunday, October 25, 2009 |
4:05PM |
BUF 20, CAR 9 |
| Regular Season: Week 8 |
 Texans |
at |
Bills |
Sunday, November 1, 2009 |
1:00PM |
HOU 31, BUF 10 |
| Regular Season: Week 10 |
Bills |
at |
 Titans |
Sunday, November 15, 2009 |
1:00PM |
BUF 17, TEN 41 |
| Regular Season: Week 11 |
Bills |
at |
 Jaguars |
Sunday, November 22, 2009 |
1:00PM |
BUF 15, JAC 18 |
| Regular Season: Week 12 |
Dolphins |
at |
Bills |
Sunday, November 29, 2009 |
1:00PM |
MIA 14, BUF 31 |
| Regular Season: Week 13 |
Jets |
at |
Bills |
Thursday, December 3, 2009 |
8:20PM |
NYJ 19, BUF 13 |
| Regular Season: Week 14 |
Bills |
at |
 Chiefs |
Sunday, December 13, 2009 |
1:00PM |
BUF 16, KC 10 |
| Regular Season: Week 15 |
Patriots |
at |
Bills |
Sunday, December 20, 2009 |
1:00PM |
NE 17, BUF 10 |
| Regular Season: Week 16 |
Bills |
at |
 Falcons |
Sunday, December 27, 2009 |
1:00PM |
BUF 3, ATL 31 |
| Regular Season: Week 17 |
 Colts |
at |
Bills |
Sunday, January 3, 2010 |
1:00PM |
IND 7, BUF 30 |