| Regular Season: Week 1 |
 Dolphins |
at |
 Bills |
Sunday, September 12, 2010 |
1:00PM |
MIA 15, BUF 10 |
| Regular Season: Week 2 |
Bills |
at |
 Packers |
Sunday, September 19, 2010 |
1:00PM |
BUF 7, GB 34 |
| Regular Season: Week 3 |
Bills |
at |
 Patriots |
Sunday, September 26, 2010 |
1:00PM |
BUF 30, NE 38 |
| Regular Season: Week 4 |
 Jets |
at |
Bills |
Sunday, October 3, 2010 |
1:00PM |
NYJ 38, BUF 14 |
| Regular Season: Week 5 |
 Jaguars |
at |
Bills |
Sunday, October 10, 2010 |
1:00PM |
JAC 36, BUF 26 |
| Regular Season: Week 7 |
Bills |
at |
 Ravens |
Sunday, October 24, 2010 |
1:00PM |
BUF 34, BAL 37 |
| Regular Season: Week 8 |
Bills |
at |
 Chiefs |
Sunday, October 31, 2010 |
1:00PM |
BUF 10, KC 13 |
| Regular Season: Week 9 |
 Bears |
at |
Bills |
Sunday, November 7, 2010 |
1:00PM |
CHI 22, BUF 19 |
| Regular Season: Week 10 |
 Lions |
at |
Bills |
Sunday, November 14, 2010 |
1:00PM |
DET 12, BUF 14 |
| Regular Season: Week 11 |
Bills |
at |
 Bengals |
Sunday, November 21, 2010 |
1:00PM |
BUF 49, CIN 31 |
| Regular Season: Week 12 |
 Steelers |
at |
Bills |
Sunday, November 28, 2010 |
1:00PM |
PIT 19, BUF 16 |
| Regular Season: Week 13 |
Bills |
at |
 Vikings |
Sunday, December 5, 2010 |
1:00PM |
BUF 14, MIN 38 |
| Regular Season: Week 14 |
 Browns |
at |
Bills |
Sunday, December 12, 2010 |
1:00PM |
CLE 6, BUF 13 |
| Regular Season: Week 15 |
Bills |
at |
Dolphins |
Sunday, December 19, 2010 |
1:00PM |
BUF 17, MIA 14 |
| Regular Season: Week 16 |
Patriots |
at |
Bills |
Sunday, December 26, 2010 |
1:00PM |
NE 34, BUF 3 |
| Regular Season: Week 17 |
Bills |
at |
Jets |
Sunday, January 2, 2011 |
1:00PM |
BUF 7, NYJ 38 |