| Regular Season: Week 1 |
 Colts |
at |
 Bills |
Sunday, September 13, 2015 |
1:00PM |
IND 14, BUF 27 |
| Regular Season: Week 2 |
 Patriots |
at |
Bills |
Sunday, September 20, 2015 |
1:00PM |
NE 40, BUF 32 |
| Regular Season: Week 3 |
Bills |
at |
 Dolphins |
Sunday, September 27, 2015 |
4:25PM |
BUF 41, MIA 14 |
| Regular Season: Week 4 |
 Giants |
at |
Bills |
Sunday, October 4, 2015 |
1:00PM |
NYG 24, BUF 10 |
| Regular Season: Week 5 |
Bills |
at |
 Titans |
Sunday, October 11, 2015 |
1:00PM |
BUF 14, TEN 13 |
| Regular Season: Week 6 |
 Bengals |
at |
Bills |
Sunday, October 18, 2015 |
1:00PM |
CIN 34, BUF 21 |
| Regular Season: Week 7 |
Bills |
at |
 Jaguars |
Sunday, October 25, 2015 |
9:30PM |
BUF 31, JAC 34 |
| Regular Season: Week 9 |
Dolphins |
at |
Bills |
Sunday, November 8, 2015 |
1:00PM |
MIA 17, BUF 33 |
| Regular Season: Week 10 |
Bills |
at |
 Jets |
Thursday, November 12, 2015 |
8:25PM |
BUF 22, NYJ 17 |
| Regular Season: Week 11 |
Bills |
at |
Patriots |
Monday, November 23, 2015 |
8:30PM |
BUF 13, NE 20 |
| Regular Season: Week 12 |
Bills |
at |
 Chiefs |
Sunday, November 29, 2015 |
1:00PM |
BUF 22, KC 30 |
| Regular Season: Week 13 |
 Texans |
at |
Bills |
Sunday, December 6, 2015 |
1:00PM |
HOU 21, BUF 30 |
| Regular Season: Week 14 |
Bills |
at |
 Eagles |
Sunday, December 13, 2015 |
1:00PM |
BUF 20, PHI 23 |
| Regular Season: Week 15 |
Bills |
at |
 Redskins |
Sunday, December 20, 2015 |
1:00PM |
BUF 25, WAS 35 |
| Regular Season: Week 16 |
 Cowboys |
at |
Bills |
Sunday, December 27, 2015 |
1:00PM |
DAL 6, BUF 16 |
| Regular Season: Week 17 |
Jets |
at |
Bills |
Sunday, January 3, 2016 |
1:00PM |
NYJ 17, BUF 22 |