| Regular Season: Week 1 |
 Bills |
at |
 Ravens |
Sunday, September 11, 2016 |
1:00PM |
BUF 7, BAL 13 |
| Regular Season: Week 2 |
 Jets |
at |
Bills |
Thursday, September 15, 2016 |
8:25PM |
NYJ 37, BUF 31 |
| Regular Season: Week 3 |
 Cardinals |
at |
Bills |
Sunday, September 25, 2016 |
1:00PM |
ARI 18, BUF 33 |
| Regular Season: Week 4 |
Bills |
at |
 Patriots |
Sunday, October 2, 2016 |
1:00PM |
BUF 16, NE 0 |
| Regular Season: Week 5 |
Bills |
at |
 Rams |
Sunday, October 9, 2016 |
4:25PM |
BUF 30, LA 19 |
| Regular Season: Week 6 |
 49ers |
at |
Bills |
Sunday, October 16, 2016 |
1:00PM |
SF 16, BUF 45 |
| Regular Season: Week 7 |
Bills |
at |
 Dolphins |
Sunday, October 23, 2016 |
1:00PM |
BUF 25, MIA 28 |
| Regular Season: Week 8 |
Patriots |
at |
Bills |
Sunday, October 30, 2016 |
1:00PM |
NE 41, BUF 25 |
| Regular Season: Week 9 |
Bills |
at |
 Seahawks |
Monday, November 7, 2016 |
8:30PM |
BUF 25, SEA 31 |
| Regular Season: Week 11 |
Bills |
at |
 Bengals |
Sunday, November 20, 2016 |
1:00PM |
BUF 16, CIN 12 |
| Regular Season: Week 12 |
 Jaguars |
at |
Bills |
Sunday, November 27, 2016 |
1:00PM |
JAX 21, BUF 28 |
| Regular Season: Week 13 |
Bills |
at |
 Raiders |
Sunday, December 4, 2016 |
4:05PM |
BUF 24, OAK 38 |
| Regular Season: Week 14 |
 Steelers |
at |
Bills |
Sunday, December 11, 2016 |
1:00PM |
PIT 27, BUF 20 |
| Regular Season: Week 15 |
 Browns |
at |
Bills |
Sunday, December 18, 2016 |
1:00PM |
CLE 13, BUF 33 |
| Regular Season: Week 16 |
Dolphins |
at |
Bills |
Saturday, December 24, 2016 |
1:00PM |
MIA 34, BUF 31 |
| Regular Season: Week 17 |
Bills |
at |
Jets |
Sunday, January 1, 2017 |
1:00PM |
BUF 10, NYJ 30 |