| Regular Season: Week 1 |
 Bills |
at |
 Ravens |
Sunday, September 9, 2018 |
1:00PM |
BUF 3, BAL 47 |
| Regular Season: Week 2 |
 Chargers |
at |
Bills |
Sunday, September 16, 2018 |
1:00PM |
LAC 31, BUF 20 |
| Regular Season: Week 3 |
Bills |
at |
 Vikings |
Sunday, September 23, 2018 |
1:00PM |
BUF 27, MIN 6 |
| Regular Season: Week 4 |
Bills |
at |
 Packers |
Sunday, September 30, 2018 |
1:00PM |
BUF 0, GB 22 |
| Regular Season: Week 5 |
 Titans |
at |
Bills |
Sunday, October 7, 2018 |
1:00PM |
TEN 12, BUF 13 |
| Regular Season: Week 6 |
Bills |
at |
 Texans |
Sunday, October 14, 2018 |
1:00PM |
BUF 13, HOU 20 |
| Regular Season: Week 7 |
Bills |
at |
 Colts |
Sunday, October 21, 2018 |
1:00PM |
BUF 5, IND 37 |
| Regular Season: Week 8 |
 Patriots |
at |
Bills |
Monday, October 29, 2018 |
8:15PM |
NE 25, BUF 6 |
| Regular Season: Week 9 |
 Bears |
at |
Bills |
Sunday, November 4, 2018 |
1:00PM |
CHI 41, BUF 9 |
| Regular Season: Week 10 |
Bills |
at |
 Jets |
Sunday, November 11, 2018 |
1:00PM |
BUF 41, NYJ 10 |
| Regular Season: Week 12 |
 Jaguars |
at |
Bills |
Sunday, November 25, 2018 |
1:00PM |
JAX 21, BUF 24 |
| Regular Season: Week 13 |
Bills |
at |
 Dolphins |
Sunday, December 2, 2018 |
1:00PM |
BUF 17, MIA 21 |
| Regular Season: Week 14 |
Jets |
at |
Bills |
Sunday, December 9, 2018 |
1:00PM |
NYJ 27, BUF 23 |
| Regular Season: Week 15 |
 Lions |
at |
Bills |
Sunday, December 16, 2018 |
1:00PM |
DET 13, BUF 14 |
| Regular Season: Week 16 |
Bills |
at |
Patriots |
Sunday, December 23, 2018 |
1:00PM |
BUF 12, NE 24 |
| Regular Season: Week 17 |
Dolphins |
at |
Bills |
Sunday, December 30, 2018 |
1:00PM |
MIA 17, BUF 42 |