| Regular Season: Week 1 |
 Bills |
at |
 Jets |
Sunday, September 8, 2019 |
1:00PM |
BUF 17, NYJ 16 |
| Regular Season: Week 2 |
Bills |
at |
 Giants |
Sunday, September 15, 2019 |
1:00PM |
BUF 28, NYG 14 |
| Regular Season: Week 3 |
 Bengals |
at |
Bills |
Sunday, September 22, 2019 |
1:00PM |
CIN 17, BUF 21 |
| Regular Season: Week 4 |
 Patriots |
at |
Bills |
Sunday, September 29, 2019 |
1:00PM |
NE 16, BUF 10 |
| Regular Season: Week 5 |
Bills |
at |
 Titans |
Sunday, October 6, 2019 |
1:00PM |
BUF 14, TEN 7 |
| Regular Season: Week 7 |
 Dolphins |
at |
Bills |
Sunday, October 20, 2019 |
1:00PM |
MIA 21, BUF 31 |
| Regular Season: Week 8 |
 Eagles |
at |
Bills |
Sunday, October 27, 2019 |
1:00PM |
PHI 31, BUF 13 |
| Regular Season: Week 9 |
 Redskins |
at |
Bills |
Sunday, November 3, 2019 |
1:00PM |
WAS 9, BUF 24 |
| Regular Season: Week 10 |
Bills |
at |
 Browns |
Sunday, November 10, 2019 |
1:00PM |
BUF 16, CLE 19 |
| Regular Season: Week 11 |
Bills |
at |
Dolphins |
Sunday, November 17, 2019 |
1:00PM |
BUF 37, MIA 20 |
| Regular Season: Week 12 |
 Broncos |
at |
Bills |
Sunday, November 24, 2019 |
1:00PM |
DEN 3, BUF 20 |
| Regular Season: Week 13 |
Bills |
at |
 Cowboys |
Thursday, November 28, 2019 |
4:30PM |
BUF 26, DAL 15 |
| Regular Season: Week 14 |
 Ravens |
at |
Bills |
Sunday, December 8, 2019 |
1:00PM |
BAL 24, BUF 17 |
| Regular Season: Week 15 |
Bills |
at |
 Steelers |
Sunday, December 15, 2019 |
8:20PM |
BUF 17, PIT 10 |
| Regular Season: Week 16 |
Bills |
at |
Patriots |
Saturday, December 21, 2019 |
4:30PM |
BUF 17, NE 24 |
| Regular Season: Week 17 |
Jets |
at |
Bills |
Sunday, December 29, 2019 |
1:00PM |
NYJ 13, BUF 6 |
| Wild Card: Week 18 |
Bills |
at |
 Texans |
Saturday, January 4, 2020 |
4:35PM |
BUF 19, HOU 22 |