| Regular Season: Week 1 |
 Jets |
at |
 Bills |
Sunday, September 13, 2020 |
1:00PM |
NYJ 17, BUF 27 |
| Regular Season: Week 2 |
Bills |
at |
 Dolphins |
Sunday, September 20, 2020 |
1:00PM |
BUF 31, MIA 28 |
| Regular Season: Week 3 |
 Rams |
at |
Bills |
Sunday, September 27, 2020 |
1:00PM |
LA 32, BUF 35 |
| Regular Season: Week 4 |
Bills |
at |
 Raiders |
Sunday, October 4, 2020 |
4:25PM |
BUF 30, LV 23 |
| Regular Season: Week 5 |
Bills |
at |
 Titans |
Tuesday, October 13, 2020 |
7:00PM |
BUF 16, TEN 42 |
| Regular Season: Week 6 |
 Chiefs |
at |
Bills |
Monday, October 19, 2020 |
5:00PM |
KC 26, BUF 17 |
| Regular Season: Week 7 |
Bills |
at |
Jets |
Sunday, October 25, 2020 |
1:00PM |
BUF 18, NYJ 10 |
| Regular Season: Week 8 |
 Patriots |
at |
Bills |
Sunday, November 1, 2020 |
1:00PM |
NE 21, BUF 24 |
| Regular Season: Week 9 |
 Seahawks |
at |
Bills |
Sunday, November 8, 2020 |
1:00PM |
SEA 34, BUF 44 |
| Regular Season: Week 10 |
Bills |
at |
 Cardinals |
Sunday, November 15, 2020 |
4:05PM |
BUF 30, ARI 32 |
| Regular Season: Week 12 |
 Chargers |
at |
Bills |
Sunday, November 29, 2020 |
1:00PM |
LAC 17, BUF 27 |
| Regular Season: Week 13 |
Bills |
at |
 49ers |
Monday, December 7, 2020 |
8:15PM |
BUF 34, SF 24 |
| Regular Season: Week 14 |
 Steelers |
at |
Bills |
Sunday, December 13, 2020 |
8:20PM |
PIT 15, BUF 26 |
| Regular Season: Week 15 |
Bills |
at |
 Broncos |
Saturday, December 19, 2020 |
4:30PM |
BUF 48, DEN 19 |
| Regular Season: Week 16 |
Bills |
at |
Patriots |
Monday, December 28, 2020 |
8:15PM |
BUF 38, NE 9 |
| Regular Season: Week 17 |
Dolphins |
at |
Bills |
Sunday, January 3, 2021 |
1:00PM |
MIA 26, BUF 56 |
| Wild Card: Week 18 |
 Colts |
at |
Bills |
Saturday, January 9, 2021 |
1:05PM |
IND 24, BUF 27 |
| Divisional Playoffs: Week 19 |
 Ravens |
at |
Bills |
Saturday, January 16, 2021 |
8:15PM |
BAL 3, BUF 17 |
| Conference Championship: Week 20 |
Bills |
at |
Chiefs |
Sunday, January 24, 2021 |
6:40PM |
BUF 24, KC 38 |