| Regular Season: Week 1 |
 Broncos |
at |
 Eagles |
Sunday, September 7, 1980 |
3:00PM |
DEN 6, PHI 27 |
| Regular Season: Week 2 |
 Cowboys |
at |
Broncos |
Sunday, September 14, 1980 |
3:00PM |
DAL 20, DEN 41 |
| Regular Season: Week 3 |
 Chargers |
at |
Broncos |
Sunday, September 21, 1980 |
3:00PM |
SD 30, DEN 13 |
| Regular Season: Week 4 |
Broncos |
at |
 Patriots |
Monday, September 29, 1980 |
3:00PM |
DEN 14, NE 23 |
| Regular Season: Week 5 |
Broncos |
at |
 Browns |
Sunday, October 5, 1980 |
3:00PM |
DEN 19, CLE 16 |
| Regular Season: Week 6 |
 Redskins |
at |
Broncos |
Monday, October 13, 1980 |
3:00PM |
WAS 17, DEN 20 |
| Regular Season: Week 7 |
 Chiefs |
at |
Broncos |
Sunday, October 19, 1980 |
3:00PM |
KC 23, DEN 17 |
| Regular Season: Week 8 |
Broncos |
at |
 Giants |
Sunday, October 26, 1980 |
2:00PM |
DEN 14, NYG 9 |
| Regular Season: Week 9 |
 Oilers |
at |
Broncos |
Sunday, November 2, 1980 |
3:00PM |
HOU 20, DEN 16 |
| Regular Season: Week 10 |
Broncos |
at |
Chargers |
Sunday, November 9, 1980 |
3:00PM |
DEN 20, SD 13 |
| Regular Season: Week 11 |
 Jets |
at |
Broncos |
Sunday, November 16, 1980 |
3:00PM |
NYJ 24, DEN 31 |
| Regular Season: Week 12 |
 Seahawks |
at |
Broncos |
Sunday, November 23, 1980 |
3:00PM |
SEA 20, DEN 36 |
| Regular Season: Week 13 |
Broncos |
at |
 Raiders |
Monday, December 1, 1980 |
3:00PM |
DEN 3, OAK 9 |
| Regular Season: Week 14 |
Broncos |
at |
Chiefs |
Sunday, December 7, 1980 |
3:00PM |
DEN 14, KC 31 |
| Regular Season: Week 15 |
Raiders |
at |
Broncos |
Sunday, December 14, 1980 |
3:00PM |
OAK 24, DEN 21 |
| Regular Season: Week 16 |
Broncos |
at |
Seahawks |
Sunday, December 21, 1980 |
3:00PM |
DEN 25, SEA 17 |