| Regular Season: Week 1 |
 Raiders |
at |
 Broncos |
Sunday, September 6, 1981 |
3:00PM |
OAK 7, DEN 9 |
| Regular Season: Week 2 |
Broncos |
at |
 Seahawks |
Sunday, September 13, 1981 |
3:00PM |
DEN 10, SEA 13 |
| Regular Season: Week 3 |
 Colts |
at |
Broncos |
Sunday, September 20, 1981 |
3:00PM |
BAL 10, DEN 28 |
| Regular Season: Week 4 |
 Chargers |
at |
Broncos |
Sunday, September 27, 1981 |
3:00PM |
SD 24, DEN 42 |
| Regular Season: Week 5 |
Broncos |
at |
Raiders |
Sunday, October 4, 1981 |
3:00PM |
DEN 17, OAK 0 |
| Regular Season: Week 6 |
 Lions |
at |
Broncos |
Sunday, October 11, 1981 |
3:00PM |
DET 21, DEN 27 |
| Regular Season: Week 7 |
Broncos |
at |
 Chiefs |
Sunday, October 18, 1981 |
3:00PM |
DEN 14, KC 28 |
| Regular Season: Week 8 |
Broncos |
at |
 Bills |
Sunday, October 25, 1981 |
2:00PM |
DEN 7, BUF 9 |
| Regular Season: Week 9 |
 Vikings |
at |
Broncos |
Monday, November 2, 1981 |
3:00PM |
MIN 17, DEN 19 |
| Regular Season: Week 10 |
 Browns |
at |
Broncos |
Sunday, November 8, 1981 |
3:00PM |
CLE 20, DEN 23 |
| Regular Season: Week 11 |
Broncos |
at |
 Buccaneers |
Sunday, November 15, 1981 |
3:00PM |
DEN 24, TB 7 |
| Regular Season: Week 12 |
Broncos |
at |
 Bengals |
Sunday, November 22, 1981 |
3:00PM |
DEN 21, CIN 38 |
| Regular Season: Week 13 |
Broncos |
at |
Chargers |
Sunday, November 29, 1981 |
3:00PM |
DEN 17, SD 34 |
| Regular Season: Week 14 |
Chiefs |
at |
Broncos |
Sunday, December 6, 1981 |
3:00PM |
KC 13, DEN 16 |
| Regular Season: Week 15 |
Seahawks |
at |
Broncos |
Sunday, December 13, 1981 |
3:00PM |
SEA 13, DEN 23 |
| Regular Season: Week 16 |
Broncos |
at |
 Bears |
Sunday, December 20, 1981 |
3:00PM |
DEN 24, CHI 35 |