| Regular Season: Week 1 |
 Seahawks |
at |
 Broncos |
Sunday, September 4, 1988 |
3:00PM |
SEA 21, DEN 14 |
| Regular Season: Week 2 |
 Chargers |
at |
Broncos |
Sunday, September 11, 1988 |
3:00PM |
SD 3, DEN 34 |
| Regular Season: Week 3 |
Broncos |
at |
 Chiefs |
Sunday, September 18, 1988 |
3:00PM |
DEN 13, KC 20 |
| Regular Season: Week 4 |
 Raiders |
at |
Broncos |
Monday, September 26, 1988 |
3:00PM |
RAI 30, DEN 27 |
| Regular Season: Week 5 |
Broncos |
at |
Chargers |
Sunday, October 2, 1988 |
3:00PM |
DEN 12, SD 0 |
| Regular Season: Week 6 |
Broncos |
at |
 49ers |
Sunday, October 9, 1988 |
3:00PM |
DEN 16, SF 13 |
| Regular Season: Week 7 |
 Falcons |
at |
Broncos |
Sunday, October 16, 1988 |
3:00PM |
ATL 14, DEN 30 |
| Regular Season: Week 8 |
Broncos |
at |
 Steelers |
Sunday, October 23, 1988 |
3:00PM |
DEN 21, PIT 39 |
| Regular Season: Week 9 |
Broncos |
at |
 Colts |
Monday, October 31, 1988 |
3:00PM |
DEN 23, IND 55 |
| Regular Season: Week 10 |
Chiefs |
at |
Broncos |
Sunday, November 6, 1988 |
3:00PM |
KC 11, DEN 17 |
| Regular Season: Week 11 |
 Browns |
at |
Broncos |
Sunday, November 13, 1988 |
3:00PM |
CLE 7, DEN 30 |
| Regular Season: Week 12 |
Broncos |
at |
 Saints |
Sunday, November 20, 1988 |
3:00PM |
DEN 0, NO 42 |
| Regular Season: Week 13 |
 Rams |
at |
Broncos |
Sunday, November 27, 1988 |
3:00PM |
RAM 24, DEN 35 |
| Regular Season: Week 14 |
Broncos |
at |
Raiders |
Sunday, December 4, 1988 |
3:00PM |
DEN 20, RAI 21 |
| Regular Season: Week 15 |
Broncos |
at |
Seahawks |
Sunday, December 11, 1988 |
3:00PM |
DEN 14, SEA 42 |
| Regular Season: Week 16 |
 Patriots |
at |
Broncos |
Saturday, December 17, 1988 |
3:00PM |
NE 10, DEN 21 |