| Regular Season: Week 1 |
 Broncos |
at |
 Giants |
Sunday, September 12, 2021 |
4:25PM |
DEN 27, NYG 13 |
| Regular Season: Week 2 |
Broncos |
at |
 Jaguars |
Sunday, September 19, 2021 |
1:00PM |
DEN 23, JAX 13 |
| Regular Season: Week 3 |
 Jets |
at |
Broncos |
Sunday, September 26, 2021 |
4:05PM |
NYJ 0, DEN 26 |
| Regular Season: Week 4 |
 Ravens |
at |
Broncos |
Sunday, October 3, 2021 |
4:25PM |
BAL 23, DEN 7 |
| Regular Season: Week 5 |
Broncos |
at |
 Steelers |
Sunday, October 10, 2021 |
1:00PM |
DEN 19, PIT 27 |
| Regular Season: Week 6 |
 Raiders |
at |
Broncos |
Sunday, October 17, 2021 |
4:25PM |
LV 34, DEN 24 |
| Regular Season: Week 7 |
Broncos |
at |
 Browns |
Thursday, October 21, 2021 |
8:20PM |
DEN 14, CLE 17 |
| Regular Season: Week 8 |
 Washington |
at |
Broncos |
Sunday, October 31, 2021 |
4:25PM |
WSH 10, DEN 17 |
| Regular Season: Week 9 |
Broncos |
at |
 Cowboys |
Sunday, November 7, 2021 |
1:00PM |
DEN 30, DAL 16 |
| Regular Season: Week 10 |
 Eagles |
at |
Broncos |
Sunday, November 14, 2021 |
4:25PM |
PHI 30, DEN 13 |
| Regular Season: Week 12 |
 Chargers |
at |
Broncos |
Sunday, November 28, 2021 |
4:05PM |
LAC 13, DEN 28 |
| Regular Season: Week 13 |
Broncos |
at |
 Chiefs |
Sunday, December 5, 2021 |
1:00PM |
DEN 9, KC 22 |
| Regular Season: Week 14 |
 Lions |
at |
Broncos |
Sunday, December 12, 2021 |
4:05PM |
DET 10, DEN 38 |
| Regular Season: Week 15 |
 Bengals |
at |
Broncos |
Sunday, December 19, 2021 |
4:05PM |
CIN 15, DEN 10 |
| Regular Season: Week 16 |
Broncos |
at |
Raiders |
Sunday, December 26, 2021 |
4:25PM |
DEN 13, LV 17 |
| Regular Season: Week 17 |
Broncos |
at |
Chargers |
Sunday, January 2, 2022 |
4:05PM |
DEN 13, LAC 34 |
| Regular Season: Week 18 |
Chiefs |
at |
Broncos |
Sunday, January 9, 2022 |
4:25PM |
KC 28, DEN 24 |