| Regular Season: Week 1 |
 49ers |
at |
 Browns |
Sunday, September 3, 1978 |
3:00PM |
SF 7, CLE 24 |
| Regular Season: Week 2 |
 Bengals |
at |
Browns |
Sunday, September 10, 1978 |
3:00PM |
CIN 10, CLE 13 |
| Regular Season: Week 3 |
Browns |
at |
 Falcons |
Sunday, September 17, 1978 |
3:00PM |
CLE 24, ATL 16 |
| Regular Season: Week 4 |
Browns |
at |
 Steelers |
Sunday, September 24, 1978 |
3:00PM |
CLE 9, PIT 15 |
| Regular Season: Week 5 |
 Oilers |
at |
Browns |
Sunday, October 1, 1978 |
3:00PM |
HOU 16, CLE 13 |
| Regular Season: Week 6 |
Browns |
at |
 Saints |
Sunday, October 8, 1978 |
3:00PM |
CLE 24, NO 16 |
| Regular Season: Week 7 |
Steelers |
at |
Browns |
Sunday, October 15, 1978 |
3:00PM |
PIT 34, CLE 14 |
| Regular Season: Week 8 |
Browns |
at |
 Chiefs |
Sunday, October 22, 1978 |
3:00PM |
CLE 3, KC 17 |
| Regular Season: Week 9 |
 Bills |
at |
Browns |
Sunday, October 29, 1978 |
2:00PM |
BUF 20, CLE 41 |
| Regular Season: Week 10 |
Browns |
at |
Oilers |
Sunday, November 5, 1978 |
3:00PM |
CLE 10, HOU 14 |
| Regular Season: Week 11 |
 Broncos |
at |
Browns |
Sunday, November 12, 1978 |
3:00PM |
DEN 19, CLE 7 |
| Regular Season: Week 12 |
Browns |
at |
 Colts |
Sunday, November 19, 1978 |
3:00PM |
CLE 45, BAL 24 |
| Regular Season: Week 13 |
 Rams |
at |
Browns |
Sunday, November 26, 1978 |
3:00PM |
LA 19, CLE 30 |
| Regular Season: Week 14 |
Browns |
at |
 Seahawks |
Sunday, December 3, 1978 |
3:00PM |
CLE 24, SEA 47 |
| Regular Season: Week 15 |
 Jets |
at |
Browns |
Sunday, December 10, 1978 |
3:00PM |
NYJ 34, CLE 37 |
| Regular Season: Week 16 |
Browns |
at |
Bengals |
Sunday, December 17, 1978 |
3:00PM |
CLE 16, CIN 48 |