| Regular Season: Week 1 |
 Browns |
at |
 Patriots |
Sunday, September 7, 1980 |
3:00PM |
CLE 17, NE 34 |
| Regular Season: Week 2 |
 Oilers |
at |
Browns |
Monday, September 15, 1980 |
3:00PM |
HOU 16, CLE 7 |
| Regular Season: Week 3 |
 Chiefs |
at |
Browns |
Sunday, September 21, 1980 |
3:00PM |
KC 13, CLE 20 |
| Regular Season: Week 4 |
Browns |
at |
 Buccaneers |
Sunday, September 28, 1980 |
3:00PM |
CLE 34, TB 27 |
| Regular Season: Week 5 |
 Broncos |
at |
Browns |
Sunday, October 5, 1980 |
3:00PM |
DEN 19, CLE 16 |
| Regular Season: Week 6 |
Browns |
at |
 Seahawks |
Sunday, October 12, 1980 |
3:00PM |
CLE 27, SEA 3 |
| Regular Season: Week 7 |
 Packers |
at |
Browns |
Sunday, October 19, 1980 |
3:00PM |
GB 21, CLE 26 |
| Regular Season: Week 8 |
 Steelers |
at |
Browns |
Sunday, October 26, 1980 |
2:00PM |
PIT 26, CLE 27 |
| Regular Season: Week 9 |
 Bears |
at |
Browns |
Monday, November 3, 1980 |
3:00PM |
CHI 21, CLE 27 |
| Regular Season: Week 10 |
Browns |
at |
 Colts |
Sunday, November 9, 1980 |
3:00PM |
CLE 28, BAL 27 |
| Regular Season: Week 11 |
Browns |
at |
Steelers |
Sunday, November 16, 1980 |
3:00PM |
CLE 13, PIT 16 |
| Regular Season: Week 12 |
 Bengals |
at |
Browns |
Sunday, November 23, 1980 |
3:00PM |
CIN 7, CLE 31 |
| Regular Season: Week 13 |
Browns |
at |
Oilers |
Sunday, November 30, 1980 |
3:00PM |
CLE 17, HOU 14 |
| Regular Season: Week 14 |
 Jets |
at |
Browns |
Sunday, December 7, 1980 |
3:00PM |
NYJ 14, CLE 17 |
| Regular Season: Week 15 |
Browns |
at |
 Vikings |
Sunday, December 14, 1980 |
3:00PM |
CLE 23, MIN 28 |
| Regular Season: Week 16 |
Browns |
at |
Bengals |
Sunday, December 21, 1980 |
3:00PM |
CLE 27, CIN 24 |
| Divisional Playoffs: Week 18 |
 Raiders |
at |
Browns |
Sunday, January 4, 1981 |
3:00PM |
OAK 14, CLE 12 |