| Regular Season: Week 1 |
 Browns |
at |
 Chiefs |
Sunday, September 4, 1988 |
3:00PM |
CLE 6, KC 3 |
| Regular Season: Week 2 |
 Jets |
at |
Browns |
Sunday, September 11, 1988 |
3:00PM |
NYJ 23, CLE 3 |
| Regular Season: Week 3 |
 Colts |
at |
Browns |
Monday, September 19, 1988 |
3:00PM |
IND 17, CLE 23 |
| Regular Season: Week 4 |
Browns |
at |
 Bengals |
Sunday, September 25, 1988 |
3:00PM |
CLE 17, CIN 24 |
| Regular Season: Week 5 |
Browns |
at |
 Steelers |
Sunday, October 2, 1988 |
3:00PM |
CLE 23, PIT 9 |
| Regular Season: Week 6 |
 Seahawks |
at |
Browns |
Sunday, October 9, 1988 |
3:00PM |
SEA 16, CLE 10 |
| Regular Season: Week 7 |
 Eagles |
at |
Browns |
Sunday, October 16, 1988 |
3:00PM |
PHI 3, CLE 19 |
| Regular Season: Week 8 |
Browns |
at |
 Cardinals |
Sunday, October 23, 1988 |
3:00PM |
CLE 29, PHO 21 |
| Regular Season: Week 9 |
Bengals |
at |
Browns |
Sunday, October 30, 1988 |
2:00PM |
CIN 16, CLE 23 |
| Regular Season: Week 10 |
Browns |
at |
 Oilers |
Monday, November 7, 1988 |
3:00PM |
CLE 17, HOU 24 |
| Regular Season: Week 11 |
Browns |
at |
 Broncos |
Sunday, November 13, 1988 |
3:00PM |
CLE 7, DEN 30 |
| Regular Season: Week 12 |
Steelers |
at |
Browns |
Sunday, November 20, 1988 |
3:00PM |
PIT 7, CLE 27 |
| Regular Season: Week 13 |
Browns |
at |
 Redskins |
Sunday, November 27, 1988 |
3:00PM |
CLE 17, WAS 13 |
| Regular Season: Week 14 |
 Cowboys |
at |
Browns |
Sunday, December 4, 1988 |
3:00PM |
DAL 21, CLE 24 |
| Regular Season: Week 15 |
Browns |
at |
 Dolphins |
Monday, December 12, 1988 |
3:00PM |
CLE 31, MIA 38 |
| Regular Season: Week 16 |
Oilers |
at |
Browns |
Sunday, December 18, 1988 |
3:00PM |
HOU 23, CLE 28 |
| Wild Card: Week 17 |
Oilers |
at |
Browns |
Saturday, December 24, 1988 |
3:00PM |
HOU 24, CLE 23 |