| Regular Season: Week 1 |
 Jaguars |
at |
 Browns |
Sunday, September 3, 2000 |
1:00PM |
JAC 27, CLE 7 |
| Regular Season: Week 2 |
Browns |
at |
 Bengals |
Sunday, September 10, 2000 |
1:00PM |
CLE 24, CIN 7 |
| Regular Season: Week 3 |
 Steelers |
at |
Browns |
Sunday, September 17, 2000 |
1:00PM |
PIT 20, CLE 23 |
| Regular Season: Week 4 |
Browns |
at |
 Raiders |
Sunday, September 24, 2000 |
4:15PM |
CLE 10, OAK 36 |
| Regular Season: Week 5 |
 Ravens |
at |
Browns |
Sunday, October 1, 2000 |
1:00PM |
BAL 12, CLE 0 |
| Regular Season: Week 6 |
Browns |
at |
 Cardinals |
Sunday, October 8, 2000 |
3:15PM |
CLE 21, ARI 29 |
| Regular Season: Week 7 |
Browns |
at |
 Broncos |
Sunday, October 15, 2000 |
4:05PM |
CLE 10, DEN 44 |
| Regular Season: Week 8 |
Browns |
at |
Steelers |
Sunday, October 22, 2000 |
4:05PM |
CLE 0, PIT 22 |
| Regular Season: Week 9 |
Bengals |
at |
Browns |
Sunday, October 29, 2000 |
1:00PM |
CIN 12, CLE 3 |
| Regular Season: Week 10 |
 Giants |
at |
Browns |
Sunday, November 5, 2000 |
1:00PM |
NYG 24, CLE 3 |
| Regular Season: Week 11 |
 Patriots |
at |
Browns |
Sunday, November 12, 2000 |
1:05PM |
NE 11, CLE 19 |
| Regular Season: Week 12 |
Browns |
at |
 Titans |
Sunday, November 19, 2000 |
1:00PM |
CLE 10, TEN 24 |
| Regular Season: Week 13 |
Browns |
at |
Ravens |
Sunday, November 26, 2000 |
1:00PM |
CLE 7, BAL 44 |
| Regular Season: Week 14 |
Browns |
at |
Jaguars |
Sunday, December 3, 2000 |
4:15PM |
CLE 0, JAC 48 |
| Regular Season: Week 15 |
 Eagles |
at |
Browns |
Sunday, December 10, 2000 |
1:00PM |
PHI 35, CLE 24 |
| Regular Season: Week 16 |
Titans |
at |
Browns |
Sunday, December 17, 2000 |
1:00PM |
TEN 24, CLE 0 |