| Regular Season: Week 1 |
 Browns |
at |
 Chiefs |
Sunday, September 12, 2021 |
4:25PM |
CLE 29, KC 33 |
| Regular Season: Week 2 |
 Texans |
at |
Browns |
Sunday, September 19, 2021 |
1:00PM |
HOU 21, CLE 31 |
| Regular Season: Week 3 |
 Bears |
at |
Browns |
Sunday, September 26, 2021 |
1:00PM |
CHI 6, CLE 26 |
| Regular Season: Week 4 |
Browns |
at |
 Vikings |
Sunday, October 3, 2021 |
1:00PM |
CLE 14, MIN 7 |
| Regular Season: Week 5 |
Browns |
at |
 Chargers |
Sunday, October 10, 2021 |
4:05PM |
CLE 42, LAC 47 |
| Regular Season: Week 6 |
 Cardinals |
at |
Browns |
Sunday, October 17, 2021 |
4:05PM |
ARI 37, CLE 14 |
| Regular Season: Week 7 |
 Broncos |
at |
Browns |
Thursday, October 21, 2021 |
8:20PM |
DEN 14, CLE 17 |
| Regular Season: Week 8 |
 Steelers |
at |
Browns |
Sunday, October 31, 2021 |
1:00PM |
PIT 15, CLE 10 |
| Regular Season: Week 9 |
Browns |
at |
 Bengals |
Sunday, November 7, 2021 |
1:00PM |
CLE 41, CIN 16 |
| Regular Season: Week 10 |
Browns |
at |
 Patriots |
Sunday, November 14, 2021 |
1:00PM |
CLE 7, NE 45 |
| Regular Season: Week 11 |
 Lions |
at |
Browns |
Sunday, November 21, 2021 |
1:00PM |
DET 10, CLE 13 |
| Regular Season: Week 12 |
Browns |
at |
 Ravens |
Sunday, November 28, 2021 |
8:20PM |
CLE 10, BAL 16 |
| Regular Season: Week 14 |
Ravens |
at |
Browns |
Sunday, December 12, 2021 |
1:00PM |
BAL 22, CLE 24 |
| Regular Season: Week 15 |
 Raiders |
at |
Browns |
Sunday, December 19, 2021 |
TBD |
LV 16, CLE 14 |
| Regular Season: Week 16 |
Browns |
at |
 Packers |
Saturday, December 25, 2021 |
4:30PM |
CLE 22, GB 24 |
| Regular Season: Week 17 |
Browns |
at |
Steelers |
Monday, January 3, 2022 |
8:15PM |
CLE 14, PIT 26 |
| Regular Season: Week 18 |
Bengals |
at |
Browns |
Sunday, January 9, 2022 |
1:00PM |
CIN 16, CLE 21 |