| Regular Season: Week 1 |
 Giants |
at |
 Buccaneers |
Saturday, September 2, 1978 |
3:00PM |
NYG 19, TB 13 |
| Regular Season: Week 2 |
 Lions |
at |
Buccaneers |
Saturday, September 9, 1978 |
3:00PM |
DET 15, TB 7 |
| Regular Season: Week 3 |
Buccaneers |
at |
 Vikings |
Sunday, September 17, 1978 |
3:00PM |
TB 16, MIN 10 |
| Regular Season: Week 4 |
 Falcons |
at |
Buccaneers |
Sunday, September 24, 1978 |
3:00PM |
ATL 9, TB 14 |
| Regular Season: Week 5 |
Vikings |
at |
Buccaneers |
Sunday, October 1, 1978 |
3:00PM |
MIN 24, TB 7 |
| Regular Season: Week 6 |
Buccaneers |
at |
 Chiefs |
Sunday, October 8, 1978 |
3:00PM |
TB 30, KC 13 |
| Regular Season: Week 7 |
Buccaneers |
at |
Giants |
Sunday, October 15, 1978 |
3:00PM |
TB 14, NYG 17 |
| Regular Season: Week 8 |
 Bears |
at |
Buccaneers |
Sunday, October 22, 1978 |
3:00PM |
CHI 19, TB 33 |
| Regular Season: Week 9 |
Buccaneers |
at |
 Packers |
Sunday, October 29, 1978 |
2:00PM |
TB 7, GB 9 |
| Regular Season: Week 10 |
Buccaneers |
at |
 Rams |
Sunday, November 5, 1978 |
3:00PM |
TB 23, LA 26 |
| Regular Season: Week 11 |
Buccaneers |
at |
Lions |
Sunday, November 12, 1978 |
3:00PM |
TB 23, DET 34 |
| Regular Season: Week 12 |
 Bills |
at |
Buccaneers |
Sunday, November 19, 1978 |
3:00PM |
BUF 10, TB 31 |
| Regular Season: Week 13 |
Buccaneers |
at |
Bears |
Sunday, November 26, 1978 |
3:00PM |
TB 3, CHI 14 |
| Regular Season: Week 14 |
Packers |
at |
Buccaneers |
Sunday, December 3, 1978 |
3:00PM |
GB 17, TB 7 |
| Regular Season: Week 15 |
Buccaneers |
at |
 49ers |
Sunday, December 10, 1978 |
3:00PM |
TB 3, SF 6 |
| Regular Season: Week 16 |
 Saints |
at |
Buccaneers |
Sunday, December 17, 1978 |
3:00PM |
NO 17, TB 10 |