| Regular Season: Week 1 |
 Buccaneers |
at |
 Bengals |
Sunday, September 7, 1980 |
3:00PM |
TB 17, CIN 12 |
| Regular Season: Week 2 |
 Rams |
at |
Buccaneers |
Thursday, September 11, 1980 |
3:00PM |
LA 9, TB 10 |
| Regular Season: Week 3 |
Buccaneers |
at |
 Cowboys |
Sunday, September 21, 1980 |
3:00PM |
TB 17, DAL 28 |
| Regular Season: Week 4 |
 Browns |
at |
Buccaneers |
Sunday, September 28, 1980 |
3:00PM |
CLE 34, TB 27 |
| Regular Season: Week 5 |
Buccaneers |
at |
 Bears |
Monday, October 6, 1980 |
3:00PM |
TB 0, CHI 23 |
| Regular Season: Week 6 |
 Packers |
at |
Buccaneers |
Sunday, October 12, 1980 |
3:00PM |
GB 14, TB 14 |
| Regular Season: Week 7 |
Buccaneers |
at |
 Oilers |
Sunday, October 19, 1980 |
3:00PM |
TB 14, HOU 20 |
| Regular Season: Week 8 |
Buccaneers |
at |
 49ers |
Sunday, October 26, 1980 |
2:00PM |
TB 24, SF 23 |
| Regular Season: Week 9 |
 Giants |
at |
Buccaneers |
Sunday, November 2, 1980 |
3:00PM |
NYG 13, TB 30 |
| Regular Season: Week 10 |
 Steelers |
at |
Buccaneers |
Sunday, November 9, 1980 |
3:00PM |
PIT 24, TB 21 |
| Regular Season: Week 11 |
Buccaneers |
at |
 Vikings |
Sunday, November 16, 1980 |
3:00PM |
TB 30, MIN 38 |
| Regular Season: Week 12 |
 Lions |
at |
Buccaneers |
Sunday, November 23, 1980 |
3:00PM |
DET 24, TB 10 |
| Regular Season: Week 13 |
Buccaneers |
at |
Packers |
Sunday, November 30, 1980 |
3:00PM |
TB 20, GB 17 |
| Regular Season: Week 14 |
Vikings |
at |
Buccaneers |
Sunday, December 7, 1980 |
3:00PM |
MIN 21, TB 10 |
| Regular Season: Week 15 |
Buccaneers |
at |
Lions |
Sunday, December 14, 1980 |
3:00PM |
TB 14, DET 27 |
| Regular Season: Week 16 |
Bears |
at |
Buccaneers |
Saturday, December 20, 1980 |
3:00PM |
CHI 14, TB 13 |