| Regular Season: Week 1 |
 Vikings |
at |
 Buccaneers |
Saturday, September 5, 1981 |
3:00PM |
MIN 13, TB 21 |
| Regular Season: Week 2 |
Buccaneers |
at |
 Chiefs |
Sunday, September 13, 1981 |
3:00PM |
TB 10, KC 19 |
| Regular Season: Week 3 |
Buccaneers |
at |
 Bears |
Sunday, September 20, 1981 |
3:00PM |
TB 17, CHI 28 |
| Regular Season: Week 4 |
 Cardinals |
at |
Buccaneers |
Sunday, September 27, 1981 |
3:00PM |
STL 10, TB 20 |
| Regular Season: Week 5 |
 Lions |
at |
Buccaneers |
Sunday, October 4, 1981 |
3:00PM |
DET 10, TB 28 |
| Regular Season: Week 6 |
Buccaneers |
at |
 Packers |
Sunday, October 11, 1981 |
3:00PM |
TB 21, GB 10 |
| Regular Season: Week 7 |
Buccaneers |
at |
 Raiders |
Sunday, October 18, 1981 |
3:00PM |
TB 16, OAK 18 |
| Regular Season: Week 8 |
Buccaneers |
at |
 Eagles |
Sunday, October 25, 1981 |
2:00PM |
TB 10, PHI 20 |
| Regular Season: Week 9 |
Bears |
at |
Buccaneers |
Sunday, November 1, 1981 |
3:00PM |
CHI 10, TB 20 |
| Regular Season: Week 10 |
Buccaneers |
at |
Vikings |
Sunday, November 8, 1981 |
3:00PM |
TB 10, MIN 25 |
| Regular Season: Week 11 |
 Broncos |
at |
Buccaneers |
Sunday, November 15, 1981 |
3:00PM |
DEN 24, TB 7 |
| Regular Season: Week 12 |
Packers |
at |
Buccaneers |
Sunday, November 22, 1981 |
3:00PM |
GB 3, TB 37 |
| Regular Season: Week 13 |
Buccaneers |
at |
 Saints |
Sunday, November 29, 1981 |
3:00PM |
TB 31, NO 14 |
| Regular Season: Week 14 |
 Falcons |
at |
Buccaneers |
Sunday, December 6, 1981 |
3:00PM |
ATL 23, TB 24 |
| Regular Season: Week 15 |
 Chargers |
at |
Buccaneers |
Sunday, December 13, 1981 |
3:00PM |
SD 24, TB 23 |
| Regular Season: Week 16 |
Buccaneers |
at |
Lions |
Sunday, December 20, 1981 |
3:00PM |
TB 20, DET 17 |
| Divisional Playoffs: Week 18 |
Buccaneers |
at |
 Cowboys |
Saturday, January 2, 1982 |
3:00PM |
TB 0, DAL 38 |