| Regular Season: Week 1 |
 Eagles |
at |
 Buccaneers |
Sunday, September 4, 1988 |
3:00PM |
PHI 41, TB 14 |
| Regular Season: Week 2 |
Buccaneers |
at |
 Packers |
Sunday, September 11, 1988 |
3:00PM |
TB 13, GB 10 |
| Regular Season: Week 3 |
 Cardinals |
at |
Buccaneers |
Sunday, September 18, 1988 |
3:00PM |
PHO 30, TB 24 |
| Regular Season: Week 4 |
Buccaneers |
at |
 Saints |
Sunday, September 25, 1988 |
3:00PM |
TB 9, NO 13 |
| Regular Season: Week 5 |
Packers |
at |
Buccaneers |
Sunday, October 2, 1988 |
3:00PM |
GB 24, TB 27 |
| Regular Season: Week 6 |
Buccaneers |
at |
 Vikings |
Sunday, October 9, 1988 |
3:00PM |
TB 13, MIN 14 |
| Regular Season: Week 7 |
Buccaneers |
at |
 Colts |
Sunday, October 16, 1988 |
3:00PM |
TB 31, IND 35 |
| Regular Season: Week 8 |
Vikings |
at |
Buccaneers |
Sunday, October 23, 1988 |
3:00PM |
MIN 49, TB 20 |
| Regular Season: Week 9 |
 Dolphins |
at |
Buccaneers |
Sunday, October 30, 1988 |
2:00PM |
MIA 17, TB 14 |
| Regular Season: Week 10 |
Buccaneers |
at |
 Bears |
Sunday, November 6, 1988 |
3:00PM |
TB 10, CHI 28 |
| Regular Season: Week 11 |
Buccaneers |
at |
 Lions |
Sunday, November 13, 1988 |
3:00PM |
TB 23, DET 20 |
| Regular Season: Week 12 |
Bears |
at |
Buccaneers |
Sunday, November 20, 1988 |
3:00PM |
CHI 27, TB 15 |
| Regular Season: Week 13 |
Buccaneers |
at |
 Falcons |
Sunday, November 27, 1988 |
3:00PM |
TB 10, ATL 17 |
| Regular Season: Week 14 |
 Bills |
at |
Buccaneers |
Sunday, December 4, 1988 |
3:00PM |
BUF 5, TB 10 |
| Regular Season: Week 15 |
Buccaneers |
at |
 Patriots |
Sunday, December 11, 1988 |
3:00PM |
TB 7, NE 10 |
| Regular Season: Week 16 |
Lions |
at |
Buccaneers |
Sunday, December 18, 1988 |
3:00PM |
DET 10, TB 21 |