| Regular Season: Week 1 |
 Buccaneers |
at |
 Patriots |
Sunday, September 3, 2000 |
1:00PM |
TB 21, NE 16 |
| Regular Season: Week 2 |
 Bears |
at |
Buccaneers |
Sunday, September 10, 2000 |
1:00PM |
CHI 0, TB 41 |
| Regular Season: Week 3 |
Buccaneers |
at |
 Lions |
Sunday, September 17, 2000 |
1:00PM |
TB 31, DET 10 |
| Regular Season: Week 4 |
 Jets |
at |
Buccaneers |
Sunday, September 24, 2000 |
4:15PM |
NYJ 21, TB 17 |
| Regular Season: Week 5 |
Buccaneers |
at |
 Redskins |
Sunday, October 1, 2000 |
4:15PM |
TB 17, WAS 20 |
| Regular Season: Week 6 |
Buccaneers |
at |
 Vikings |
Monday, October 9, 2000 |
9:00PM |
TB 23, MIN 30 |
| Regular Season: Week 8 |
Lions |
at |
Buccaneers |
Thursday, October 19, 2000 |
8:20PM |
DET 28, TB 14 |
| Regular Season: Week 9 |
Vikings |
at |
Buccaneers |
Sunday, October 29, 2000 |
1:00PM |
MIN 13, TB 41 |
| Regular Season: Week 10 |
Buccaneers |
at |
 Falcons |
Sunday, November 5, 2000 |
1:00PM |
TB 27, ATL 14 |
| Regular Season: Week 11 |
 Packers |
at |
Buccaneers |
Sunday, November 12, 2000 |
4:15PM |
GB 15, TB 20 |
| Regular Season: Week 12 |
Buccaneers |
at |
Bears |
Sunday, November 19, 2000 |
1:00PM |
TB 10, CHI 13 |
| Regular Season: Week 13 |
 Bills |
at |
Buccaneers |
Sunday, November 26, 2000 |
1:00PM |
BUF 17, TB 31 |
| Regular Season: Week 14 |
 Cowboys |
at |
Buccaneers |
Sunday, December 3, 2000 |
1:00PM |
DAL 7, TB 27 |
| Regular Season: Week 15 |
Buccaneers |
at |
 Dolphins |
Sunday, December 10, 2000 |
1:00PM |
TB 16, MIA 13 |
| Regular Season: Week 16 |
 Rams |
at |
Buccaneers |
Monday, December 18, 2000 |
9:00PM |
STL 35, TB 38 |
| Regular Season: Week 17 |
Buccaneers |
at |
Packers |
Sunday, December 24, 2000 |
1:00PM |
TB 14, GB 17 |
| Wild Card: Week 18 |
Buccaneers |
at |
 Eagles |
Sunday, December 31, 2000 |
4:15PM |
TB 3, PHI 21 |