| Regular Season: Week 1 |
 Cowboys |
at |
 Buccaneers |
Thursday, September 9, 2021 |
8:20PM |
DAL 29, TB 31 |
| Regular Season: Week 2 |
 Falcons |
at |
Buccaneers |
Sunday, September 19, 2021 |
4:05PM |
ATL 25, TB 48 |
| Regular Season: Week 3 |
Buccaneers |
at |
 Rams |
Sunday, September 26, 2021 |
4:25PM |
TB 24, LAR 34 |
| Regular Season: Week 4 |
Buccaneers |
at |
 Patriots |
Sunday, October 3, 2021 |
8:20PM |
TB 19, NE 17 |
| Regular Season: Week 5 |
 Dolphins |
at |
Buccaneers |
Sunday, October 10, 2021 |
1:00PM |
MIA 17, TB 45 |
| Regular Season: Week 6 |
Buccaneers |
at |
 Eagles |
Thursday, October 14, 2021 |
8:20PM |
TB 28, PHI 22 |
| Regular Season: Week 7 |
 Bears |
at |
Buccaneers |
Sunday, October 24, 2021 |
4:25PM |
CHI 3, TB 38 |
| Regular Season: Week 8 |
Buccaneers |
at |
 Saints |
Sunday, October 31, 2021 |
4:25PM |
TB 27, NO 36 |
| Regular Season: Week 10 |
Buccaneers |
at |
 Washington |
Sunday, November 14, 2021 |
1:00PM |
TB 19, WSH 29 |
| Regular Season: Week 11 |
 Giants |
at |
Buccaneers |
Monday, November 22, 2021 |
8:15PM |
NYG 10, TB 30 |
| Regular Season: Week 12 |
Buccaneers |
at |
 Colts |
Sunday, November 28, 2021 |
1:00PM |
TB 38, IND 31 |
| Regular Season: Week 13 |
Buccaneers |
at |
Falcons |
Sunday, December 5, 2021 |
1:00PM |
TB 30, ATL 17 |
| Regular Season: Week 14 |
 Bills |
at |
Buccaneers |
Sunday, December 12, 2021 |
4:25PM |
BUF 27, TB 33 |
| Regular Season: Week 15 |
Saints |
at |
Buccaneers |
Sunday, December 19, 2021 |
8:20PM |
NO 9, TB 0 |
| Regular Season: Week 16 |
Buccaneers |
at |
 Panthers |
Sunday, December 26, 2021 |
1:00PM |
TB 32, CAR 6 |
| Regular Season: Week 17 |
Buccaneers |
at |
 Jets |
Sunday, January 2, 2022 |
1:00PM |
TB 28, NYJ 24 |
| Regular Season: Week 18 |
Panthers |
at |
Buccaneers |
Sunday, January 9, 2022 |
1:00PM |
CAR 17, TB 41 |