| Regular Season: Week 1 |
 Rams |
at |
 Cardinals |
Monday, September 16, 1968 |
3:00PM |
LA 24, STL 13 |
| Regular Season: Week 2 |
Cardinals |
at |
 49ers |
Sunday, September 22, 1968 |
3:00PM |
STL 17, SF 35 |
| Regular Season: Week 3 |
Cardinals |
at |
 Saints |
Sunday, September 29, 1968 |
3:00PM |
STL 21, NO 20 |
| Regular Season: Week 4 |
 Cowboys |
at |
Cardinals |
Sunday, October 6, 1968 |
3:00PM |
DAL 27, STL 10 |
| Regular Season: Week 5 |
Cardinals |
at |
 Browns |
Sunday, October 13, 1968 |
3:00PM |
STL 27, CLE 21 |
| Regular Season: Week 6 |
 Redskins |
at |
Cardinals |
Sunday, October 20, 1968 |
3:00PM |
WAS 14, STL 41 |
| Regular Season: Week 7 |
Saints |
at |
Cardinals |
Sunday, October 27, 1968 |
2:00PM |
NO 17, STL 31 |
| Regular Season: Week 8 |
Cardinals |
at |
 Eagles |
Sunday, November 3, 1968 |
3:00PM |
STL 45, PHI 17 |
| Regular Season: Week 9 |
 Steelers |
at |
Cardinals |
Sunday, November 10, 1968 |
3:00PM |
PIT 28, STL 28 |
| Regular Season: Week 10 |
Cardinals |
at |
 Colts |
Sunday, November 17, 1968 |
3:00PM |
STL 0, BAL 27 |
| Regular Season: Week 11 |
 Falcons |
at |
Cardinals |
Sunday, November 24, 1968 |
3:00PM |
ATL 12, STL 17 |
| Regular Season: Week 12 |
Cardinals |
at |
Steelers |
Sunday, December 1, 1968 |
3:00PM |
STL 20, PIT 10 |
| Regular Season: Week 13 |
Cardinals |
at |
 Giants |
Sunday, December 8, 1968 |
3:00PM |
STL 28, NYG 21 |
| Regular Season: Week 14 |
Browns |
at |
Cardinals |
Saturday, December 14, 1968 |
3:00PM |
CLE 16, STL 27 |