| Regular Season: Week 1 |
 Cardinals |
at |
 Bears |
Sunday, September 3, 1978 |
3:00PM |
STL 10, CHI 17 |
| Regular Season: Week 2 |
 Patriots |
at |
Cardinals |
Sunday, September 10, 1978 |
3:00PM |
NE 16, STL 6 |
| Regular Season: Week 3 |
 Redskins |
at |
Cardinals |
Sunday, September 17, 1978 |
3:00PM |
WAS 28, STL 10 |
| Regular Season: Week 4 |
Cardinals |
at |
 Cowboys |
Sunday, September 24, 1978 |
3:00PM |
STL 12, DAL 21 |
| Regular Season: Week 5 |
Cardinals |
at |
 Dolphins |
Sunday, October 1, 1978 |
3:00PM |
STL 10, MIA 24 |
| Regular Season: Week 6 |
 Colts |
at |
Cardinals |
Sunday, October 8, 1978 |
3:00PM |
BAL 30, STL 17 |
| Regular Season: Week 7 |
Cowboys |
at |
Cardinals |
Sunday, October 15, 1978 |
3:00PM |
DAL 24, STL 21 |
| Regular Season: Week 8 |
Cardinals |
at |
 Jets |
Sunday, October 22, 1978 |
3:00PM |
STL 10, NYJ 23 |
| Regular Season: Week 9 |
Cardinals |
at |
 Eagles |
Sunday, October 29, 1978 |
2:00PM |
STL 16, PHI 10 |
| Regular Season: Week 10 |
 Giants |
at |
Cardinals |
Sunday, November 5, 1978 |
3:00PM |
NYG 10, STL 20 |
| Regular Season: Week 11 |
Cardinals |
at |
 49ers |
Sunday, November 12, 1978 |
3:00PM |
STL 16, SF 10 |
| Regular Season: Week 12 |
Cardinals |
at |
Redskins |
Sunday, November 19, 1978 |
3:00PM |
STL 27, WAS 17 |
| Regular Season: Week 13 |
Eagles |
at |
Cardinals |
Sunday, November 26, 1978 |
3:00PM |
PHI 14, STL 10 |
| Regular Season: Week 14 |
 Lions |
at |
Cardinals |
Sunday, December 3, 1978 |
3:00PM |
DET 14, STL 21 |
| Regular Season: Week 15 |
Cardinals |
at |
Giants |
Sunday, December 10, 1978 |
3:00PM |
STL 0, NYG 17 |
| Regular Season: Week 16 |
 Falcons |
at |
Cardinals |
Sunday, December 17, 1978 |
3:00PM |
ATL 21, STL 42 |