| Regular Season: Week 1 |
 Giants |
at |
 Cardinals |
Sunday, September 7, 1980 |
3:00PM |
NYG 41, STL 35 |
| Regular Season: Week 2 |
Cardinals |
at |
 49ers |
Sunday, September 14, 1980 |
3:00PM |
STL 21, SF 24 |
| Regular Season: Week 3 |
Cardinals |
at |
 Lions |
Sunday, September 21, 1980 |
3:00PM |
STL 7, DET 20 |
| Regular Season: Week 4 |
 Eagles |
at |
Cardinals |
Sunday, September 28, 1980 |
3:00PM |
PHI 14, STL 24 |
| Regular Season: Week 5 |
Cardinals |
at |
 Saints |
Sunday, October 5, 1980 |
3:00PM |
STL 40, NO 7 |
| Regular Season: Week 6 |
 Rams |
at |
Cardinals |
Sunday, October 12, 1980 |
3:00PM |
LA 21, STL 13 |
| Regular Season: Week 7 |
Cardinals |
at |
 Redskins |
Sunday, October 19, 1980 |
3:00PM |
STL 0, WAS 23 |
| Regular Season: Week 8 |
Cardinals |
at |
 Colts |
Sunday, October 26, 1980 |
2:00PM |
STL 17, BAL 10 |
| Regular Season: Week 9 |
 Cowboys |
at |
Cardinals |
Sunday, November 2, 1980 |
3:00PM |
DAL 27, STL 24 |
| Regular Season: Week 10 |
 Falcons |
at |
Cardinals |
Sunday, November 9, 1980 |
3:00PM |
ATL 33, STL 27 |
| Regular Season: Week 11 |
Cardinals |
at |
Cowboys |
Sunday, November 16, 1980 |
3:00PM |
STL 21, DAL 31 |
| Regular Season: Week 12 |
 Chiefs |
at |
Cardinals |
Sunday, November 23, 1980 |
3:00PM |
KC 21, STL 13 |
| Regular Season: Week 13 |
Cardinals |
at |
Giants |
Sunday, November 30, 1980 |
3:00PM |
STL 23, NYG 7 |
| Regular Season: Week 14 |
Lions |
at |
Cardinals |
Sunday, December 7, 1980 |
3:00PM |
DET 23, STL 24 |
| Regular Season: Week 15 |
Cardinals |
at |
Eagles |
Sunday, December 14, 1980 |
3:00PM |
STL 3, PHI 17 |
| Regular Season: Week 16 |
Redskins |
at |
Cardinals |
Sunday, December 21, 1980 |
3:00PM |
WAS 31, STL 7 |