| Regular Season: Week 1 |
 Dolphins |
at |
 Cardinals |
Sunday, September 6, 1981 |
3:00PM |
MIA 20, STL 7 |
| Regular Season: Week 2 |
Cardinals |
at |
 Cowboys |
Sunday, September 13, 1981 |
3:00PM |
STL 17, DAL 30 |
| Regular Season: Week 3 |
 Redskins |
at |
Cardinals |
Sunday, September 20, 1981 |
3:00PM |
WAS 30, STL 40 |
| Regular Season: Week 4 |
Cardinals |
at |
 Buccaneers |
Sunday, September 27, 1981 |
3:00PM |
STL 10, TB 20 |
| Regular Season: Week 5 |
Cowboys |
at |
Cardinals |
Sunday, October 4, 1981 |
3:00PM |
DAL 17, STL 20 |
| Regular Season: Week 6 |
Cardinals |
at |
 Giants |
Sunday, October 11, 1981 |
3:00PM |
STL 14, NYG 34 |
| Regular Season: Week 7 |
Cardinals |
at |
 Falcons |
Sunday, October 18, 1981 |
3:00PM |
STL 20, ATL 41 |
| Regular Season: Week 8 |
 Vikings |
at |
Cardinals |
Sunday, October 25, 1981 |
2:00PM |
MIN 17, STL 30 |
| Regular Season: Week 9 |
Cardinals |
at |
Redskins |
Sunday, November 1, 1981 |
3:00PM |
STL 21, WAS 42 |
| Regular Season: Week 10 |
 Eagles |
at |
Cardinals |
Sunday, November 8, 1981 |
3:00PM |
PHI 52, STL 10 |
| Regular Season: Week 11 |
 Bills |
at |
Cardinals |
Sunday, November 15, 1981 |
3:00PM |
BUF 0, STL 24 |
| Regular Season: Week 12 |
Cardinals |
at |
 Colts |
Sunday, November 22, 1981 |
3:00PM |
STL 35, BAL 24 |
| Regular Season: Week 13 |
Cardinals |
at |
 Patriots |
Sunday, November 29, 1981 |
3:00PM |
STL 27, NE 20 |
| Regular Season: Week 14 |
 Saints |
at |
Cardinals |
Sunday, December 6, 1981 |
3:00PM |
NO 3, STL 30 |
| Regular Season: Week 15 |
Giants |
at |
Cardinals |
Sunday, December 13, 1981 |
3:00PM |
NYG 20, STL 10 |
| Regular Season: Week 16 |
Cardinals |
at |
Eagles |
Sunday, December 20, 1981 |
3:00PM |
STL 0, PHI 38 |