| Regular Season: Week 1 |
 Cardinals |
at |
 Bengals |
Sunday, September 4, 1988 |
3:00PM |
PHO 14, CIN 21 |
| Regular Season: Week 2 |
 Cowboys |
at |
Cardinals |
Monday, September 12, 1988 |
3:00PM |
DAL 17, PHO 14 |
| Regular Season: Week 3 |
Cardinals |
at |
 Buccaneers |
Sunday, September 18, 1988 |
3:00PM |
PHO 30, TB 24 |
| Regular Season: Week 4 |
 Redskins |
at |
Cardinals |
Sunday, September 25, 1988 |
3:00PM |
WAS 21, PHO 30 |
| Regular Season: Week 5 |
Cardinals |
at |
 Rams |
Sunday, October 2, 1988 |
3:00PM |
PHO 41, RAM 27 |
| Regular Season: Week 6 |
 Steelers |
at |
Cardinals |
Sunday, October 9, 1988 |
3:00PM |
PIT 14, PHO 31 |
| Regular Season: Week 7 |
Cardinals |
at |
Redskins |
Sunday, October 16, 1988 |
3:00PM |
PHO 17, WAS 33 |
| Regular Season: Week 8 |
 Browns |
at |
Cardinals |
Sunday, October 23, 1988 |
3:00PM |
CLE 29, PHO 21 |
| Regular Season: Week 9 |
Cardinals |
at |
Cowboys |
Sunday, October 30, 1988 |
2:00PM |
PHO 16, DAL 10 |
| Regular Season: Week 10 |
 49ers |
at |
Cardinals |
Sunday, November 6, 1988 |
3:00PM |
SF 23, PHO 24 |
| Regular Season: Week 11 |
 Giants |
at |
Cardinals |
Sunday, November 13, 1988 |
3:00PM |
NYG 17, PHO 24 |
| Regular Season: Week 12 |
Cardinals |
at |
 Oilers |
Sunday, November 20, 1988 |
3:00PM |
PHO 20, HOU 38 |
| Regular Season: Week 13 |
Cardinals |
at |
 Eagles |
Sunday, November 27, 1988 |
3:00PM |
PHO 21, PHI 31 |
| Regular Season: Week 14 |
Cardinals |
at |
Giants |
Sunday, December 4, 1988 |
3:00PM |
PHO 7, NYG 44 |
| Regular Season: Week 15 |
Eagles |
at |
Cardinals |
Saturday, December 10, 1988 |
3:00PM |
PHI 23, PHO 17 |
| Regular Season: Week 16 |
 Packers |
at |
Cardinals |
Sunday, December 18, 1988 |
3:00PM |
GB 26, PHO 17 |