| Regular Season: Week 1 |
 Bills |
at |
 Chargers |
Sunday, September 4, 1966 |
3:00PM |
BUF 7, SD 27 |
| Regular Season: Week 2 |
 Patriots |
at |
Chargers |
Saturday, September 10, 1966 |
3:00PM |
BOS 0, SD 24 |
| Regular Season: Week 4 |
Chargers |
at |
 Raiders |
Sunday, September 25, 1966 |
3:00PM |
SD 29, OAK 20 |
| Regular Season: Week 5 |
 Dolphins |
at |
Chargers |
Sunday, October 2, 1966 |
3:00PM |
MIA 10, SD 44 |
| Regular Season: Week 6 |
Chargers |
at |
 Jets |
Saturday, October 8, 1966 |
3:00PM |
SD 16, NYJ 17 |
| Regular Season: Week 7 |
Chargers |
at |
Bills |
Sunday, October 16, 1966 |
3:00PM |
SD 17, BUF 17 |
| Regular Season: Week 8 |
Chargers |
at |
Patriots |
Sunday, October 23, 1966 |
3:00PM |
SD 17, BOS 35 |
| Regular Season: Week 9 |
 Broncos |
at |
Chargers |
Sunday, October 30, 1966 |
2:00PM |
DEN 17, SD 24 |
| Regular Season: Week 10 |
Chargers |
at |
 Chiefs |
Sunday, November 6, 1966 |
3:00PM |
SD 14, KC 24 |
| Regular Season: Week 11 |
Raiders |
at |
Chargers |
Sunday, November 13, 1966 |
3:00PM |
OAK 41, SD 19 |
| Regular Season: Week 13 |
Chargers |
at |
Broncos |
Sunday, November 27, 1966 |
3:00PM |
SD 17, DEN 20 |
| Regular Season: Week 14 |
Chargers |
at |
 Oilers |
Sunday, December 4, 1966 |
3:00PM |
SD 28, HOU 22 |
| Regular Season: Week 15 |
Jets |
at |
Chargers |
Sunday, December 11, 1966 |
3:00PM |
NYJ 27, SD 42 |
| Regular Season: Week 16 |
Chiefs |
at |
Chargers |
Sunday, December 18, 1966 |
3:00PM |
KC 27, SD 17 |