| Regular Season: Week 1 |
 Bengals |
at |
 Chargers |
Friday, September 6, 1968 |
3:00PM |
CIN 13, SD 29 |
| Regular Season: Week 2 |
 Oilers |
at |
Chargers |
Saturday, September 21, 1968 |
3:00PM |
HOU 14, SD 30 |
| Regular Season: Week 3 |
Chargers |
at |
Bengals |
Sunday, September 29, 1968 |
3:00PM |
SD 31, CIN 10 |
| Regular Season: Week 4 |
Chargers |
at |
 Jets |
Saturday, October 5, 1968 |
3:00PM |
SD 20, NYJ 23 |
| Regular Season: Week 5 |
Chargers |
at |
 Raiders |
Sunday, October 13, 1968 |
3:00PM |
SD 23, OAK 14 |
| Regular Season: Week 6 |
 Broncos |
at |
Chargers |
Sunday, October 20, 1968 |
3:00PM |
DEN 24, SD 55 |
| Regular Season: Week 7 |
Chargers |
at |
 Chiefs |
Sunday, October 27, 1968 |
2:00PM |
SD 20, KC 27 |
| Regular Season: Week 8 |
 Dolphins |
at |
Chargers |
Sunday, November 3, 1968 |
3:00PM |
MIA 28, SD 34 |
| Regular Season: Week 9 |
Chargers |
at |
 Patriots |
Sunday, November 10, 1968 |
3:00PM |
SD 27, BOS 17 |
| Regular Season: Week 10 |
Chargers |
at |
 Bills |
Sunday, November 17, 1968 |
3:00PM |
SD 21, BUF 6 |
| Regular Season: Week 11 |
Jets |
at |
Chargers |
Sunday, November 24, 1968 |
3:00PM |
NYJ 37, SD 15 |
| Regular Season: Week 12 |
Chargers |
at |
Broncos |
Sunday, December 1, 1968 |
3:00PM |
SD 47, DEN 23 |
| Regular Season: Week 13 |
Chiefs |
at |
Chargers |
Sunday, December 8, 1968 |
3:00PM |
KC 40, SD 3 |
| Regular Season: Week 14 |
Raiders |
at |
Chargers |
Sunday, December 15, 1968 |
3:00PM |
OAK 34, SD 27 |