| Regular Season: Week 1 |
 Chargers |
at |
 49ers |
Sunday, September 17, 1972 |
3:00PM |
SD 3, SF 34 |
| Regular Season: Week 2 |
 Broncos |
at |
Chargers |
Sunday, September 24, 1972 |
3:00PM |
DEN 14, SD 37 |
| Regular Season: Week 3 |
Chargers |
at |
 Raiders |
Sunday, October 1, 1972 |
3:00PM |
SD 17, OAK 17 |
| Regular Season: Week 4 |
Chargers |
at |
 Colts |
Sunday, October 8, 1972 |
3:00PM |
SD 23, BAL 20 |
| Regular Season: Week 5 |
Chargers |
at |
 Dolphins |
Sunday, October 15, 1972 |
3:00PM |
SD 10, MIA 24 |
| Regular Season: Week 6 |
Chargers |
at |
 Lions |
Sunday, October 22, 1972 |
3:00PM |
SD 20, DET 34 |
| Regular Season: Week 7 |
 Chiefs |
at |
Chargers |
Sunday, October 29, 1972 |
2:00PM |
KC 26, SD 14 |
| Regular Season: Week 8 |
 Cowboys |
at |
Chargers |
Sunday, November 5, 1972 |
3:00PM |
DAL 34, SD 28 |
| Regular Season: Week 9 |
 Browns |
at |
Chargers |
Monday, November 13, 1972 |
3:00PM |
CLE 21, SD 17 |
| Regular Season: Week 10 |
Chargers |
at |
Chiefs |
Sunday, November 19, 1972 |
3:00PM |
SD 27, KC 17 |
| Regular Season: Week 11 |
 Oilers |
at |
Chargers |
Sunday, November 26, 1972 |
3:00PM |
HOU 20, SD 34 |
| Regular Season: Week 12 |
Raiders |
at |
Chargers |
Sunday, December 3, 1972 |
3:00PM |
OAK 21, SD 19 |
| Regular Season: Week 13 |
Chargers |
at |
Broncos |
Sunday, December 10, 1972 |
3:00PM |
SD 13, DEN 38 |
| Regular Season: Week 14 |
 Steelers |
at |
Chargers |
Sunday, December 17, 1972 |
3:00PM |
PIT 24, SD 2 |