| Regular Season: Week 1 |
 Steelers |
at |
 Chargers |
Sunday, September 21, 1975 |
3:00PM |
PIT 37, SD 0 |
| Regular Season: Week 2 |
Chargers |
at |
 Oilers |
Sunday, September 28, 1975 |
3:00PM |
SD 17, HOU 33 |
| Regular Season: Week 3 |
 Raiders |
at |
Chargers |
Sunday, October 5, 1975 |
3:00PM |
OAK 6, SD 0 |
| Regular Season: Week 4 |
 Rams |
at |
Chargers |
Sunday, October 12, 1975 |
3:00PM |
LA 13, SD 10 |
| Regular Season: Week 5 |
 Chiefs |
at |
Chargers |
Sunday, October 19, 1975 |
3:00PM |
KC 12, SD 10 |
| Regular Season: Week 6 |
Chargers |
at |
Raiders |
Sunday, October 26, 1975 |
2:00PM |
SD 0, OAK 25 |
| Regular Season: Week 7 |
Chargers |
at |
 Giants |
Saturday, November 1, 1975 |
3:00PM |
SD 24, NYG 35 |
| Regular Season: Week 8 |
 Patriots |
at |
Chargers |
Sunday, November 9, 1975 |
3:00PM |
NE 33, SD 19 |
| Regular Season: Week 9 |
 Broncos |
at |
Chargers |
Sunday, November 16, 1975 |
3:00PM |
DEN 27, SD 17 |
| Regular Season: Week 10 |
Chargers |
at |
 Vikings |
Sunday, November 23, 1975 |
3:00PM |
SD 13, MIN 28 |
| Regular Season: Week 11 |
Chargers |
at |
Broncos |
Sunday, November 30, 1975 |
3:00PM |
SD 10, DEN 13 |
| Regular Season: Week 12 |
Chargers |
at |
Chiefs |
Sunday, December 7, 1975 |
3:00PM |
SD 28, KC 20 |
| Regular Season: Week 13 |
 Jets |
at |
Chargers |
Monday, December 15, 1975 |
3:00PM |
NYJ 16, SD 24 |
| Regular Season: Week 14 |
Chargers |
at |
 Bengals |
Sunday, December 21, 1975 |
3:00PM |
SD 17, CIN 47 |