| Regular Season: Week 1 |
 Chargers |
at |
 Seahawks |
Sunday, September 3, 1978 |
3:00PM |
SD 24, SEA 20 |
| Regular Season: Week 2 |
 Raiders |
at |
Chargers |
Sunday, September 10, 1978 |
3:00PM |
OAK 21, SD 20 |
| Regular Season: Week 3 |
Chargers |
at |
 Broncos |
Sunday, September 17, 1978 |
3:00PM |
SD 14, DEN 27 |
| Regular Season: Week 4 |
 Packers |
at |
Chargers |
Sunday, September 24, 1978 |
3:00PM |
GB 24, SD 3 |
| Regular Season: Week 5 |
Chargers |
at |
 Patriots |
Sunday, October 1, 1978 |
3:00PM |
SD 23, NE 28 |
| Regular Season: Week 6 |
Broncos |
at |
Chargers |
Sunday, October 8, 1978 |
3:00PM |
DEN 0, SD 23 |
| Regular Season: Week 7 |
 Dolphins |
at |
Chargers |
Sunday, October 15, 1978 |
3:00PM |
MIA 28, SD 21 |
| Regular Season: Week 8 |
Chargers |
at |
 Lions |
Sunday, October 22, 1978 |
3:00PM |
SD 14, DET 31 |
| Regular Season: Week 9 |
Chargers |
at |
Raiders |
Sunday, October 29, 1978 |
2:00PM |
SD 27, OAK 23 |
| Regular Season: Week 10 |
 Bengals |
at |
Chargers |
Sunday, November 5, 1978 |
3:00PM |
CIN 13, SD 22 |
| Regular Season: Week 11 |
 Chiefs |
at |
Chargers |
Sunday, November 12, 1978 |
3:00PM |
KC 23, SD 29 |
| Regular Season: Week 12 |
Chargers |
at |
 Vikings |
Sunday, November 19, 1978 |
3:00PM |
SD 13, MIN 7 |
| Regular Season: Week 13 |
Chargers |
at |
Chiefs |
Sunday, November 26, 1978 |
3:00PM |
SD 0, KC 23 |
| Regular Season: Week 14 |
 Bears |
at |
Chargers |
Monday, December 4, 1978 |
3:00PM |
CHI 7, SD 40 |
| Regular Season: Week 15 |
Seahawks |
at |
Chargers |
Sunday, December 10, 1978 |
3:00PM |
SEA 10, SD 37 |
| Regular Season: Week 16 |
Chargers |
at |
 Oilers |
Sunday, December 17, 1978 |
3:00PM |
SD 45, HOU 24 |