| Regular Season: Week 1 |
 Chargers |
at |
 Seahawks |
Sunday, September 7, 1980 |
3:00PM |
SD 34, SEA 13 |
| Regular Season: Week 2 |
 Raiders |
at |
Chargers |
Sunday, September 14, 1980 |
3:00PM |
OAK 24, SD 30 |
| Regular Season: Week 3 |
Chargers |
at |
 Broncos |
Sunday, September 21, 1980 |
3:00PM |
SD 30, DEN 13 |
| Regular Season: Week 4 |
Chargers |
at |
 Chiefs |
Sunday, September 28, 1980 |
3:00PM |
SD 24, KC 7 |
| Regular Season: Week 5 |
 Bills |
at |
Chargers |
Sunday, October 5, 1980 |
3:00PM |
BUF 26, SD 24 |
| Regular Season: Week 6 |
Chargers |
at |
Raiders |
Sunday, October 12, 1980 |
3:00PM |
SD 24, OAK 38 |
| Regular Season: Week 7 |
 Giants |
at |
Chargers |
Sunday, October 19, 1980 |
3:00PM |
NYG 7, SD 44 |
| Regular Season: Week 8 |
Chargers |
at |
 Cowboys |
Sunday, October 26, 1980 |
2:00PM |
SD 31, DAL 42 |
| Regular Season: Week 9 |
Chargers |
at |
 Bengals |
Sunday, November 2, 1980 |
3:00PM |
SD 31, CIN 14 |
| Regular Season: Week 10 |
Broncos |
at |
Chargers |
Sunday, November 9, 1980 |
3:00PM |
DEN 20, SD 13 |
| Regular Season: Week 11 |
Chiefs |
at |
Chargers |
Sunday, November 16, 1980 |
3:00PM |
KC 7, SD 20 |
| Regular Season: Week 12 |
Chargers |
at |
 Dolphins |
Thursday, November 20, 1980 |
3:00PM |
SD 27, MIA 24 |
| Regular Season: Week 13 |
 Eagles |
at |
Chargers |
Sunday, November 30, 1980 |
3:00PM |
PHI 21, SD 22 |
| Regular Season: Week 14 |
Chargers |
at |
 Redskins |
Sunday, December 7, 1980 |
3:00PM |
SD 17, WAS 40 |
| Regular Season: Week 15 |
Seahawks |
at |
Chargers |
Saturday, December 13, 1980 |
3:00PM |
SEA 14, SD 21 |
| Regular Season: Week 16 |
 Steelers |
at |
Chargers |
Monday, December 22, 1980 |
3:00PM |
PIT 17, SD 26 |
| Divisional Playoffs: Week 18 |
Bills |
at |
Chargers |
Saturday, January 3, 1981 |
3:00PM |
BUF 14, SD 20 |
| Conference Championship: Week 19 |
Raiders |
at |
Chargers |
Sunday, January 11, 1981 |
3:00PM |
OAK 34, SD 27 |