| Regular Season: Week 1 |
 Chargers |
at |
 Bills |
Sunday, September 8, 1985 |
3:00PM |
SD 14, BUF 9 |
| Regular Season: Week 2 |
 Seahawks |
at |
Chargers |
Sunday, September 15, 1985 |
3:00PM |
SEA 49, SD 35 |
| Regular Season: Week 3 |
Chargers |
at |
 Bengals |
Sunday, September 22, 1985 |
3:00PM |
SD 44, CIN 41 |
| Regular Season: Week 4 |
 Browns |
at |
Chargers |
Sunday, September 29, 1985 |
3:00PM |
CLE 21, SD 7 |
| Regular Season: Week 5 |
Chargers |
at |
Seahawks |
Sunday, October 6, 1985 |
3:00PM |
SD 21, SEA 26 |
| Regular Season: Week 6 |
 Chiefs |
at |
Chargers |
Sunday, October 13, 1985 |
3:00PM |
KC 20, SD 31 |
| Regular Season: Week 7 |
Chargers |
at |
 Vikings |
Sunday, October 20, 1985 |
3:00PM |
SD 17, MIN 21 |
| Regular Season: Week 8 |
Chargers |
at |
 Raiders |
Monday, October 28, 1985 |
3:00PM |
SD 21, RAI 34 |
| Regular Season: Week 9 |
 Broncos |
at |
Chargers |
Sunday, November 3, 1985 |
3:00PM |
DEN 10, SD 30 |
| Regular Season: Week 10 |
Raiders |
at |
Chargers |
Sunday, November 10, 1985 |
3:00PM |
RAI 34, SD 40 |
| Regular Season: Week 11 |
Chargers |
at |
Broncos |
Sunday, November 17, 1985 |
3:00PM |
SD 24, DEN 30 |
| Regular Season: Week 12 |
Chargers |
at |
 Oilers |
Sunday, November 24, 1985 |
3:00PM |
SD 35, HOU 37 |
| Regular Season: Week 13 |
Bills |
at |
Chargers |
Sunday, December 1, 1985 |
3:00PM |
BUF 7, SD 40 |
| Regular Season: Week 14 |
 Steelers |
at |
Chargers |
Sunday, December 8, 1985 |
3:00PM |
PIT 44, SD 54 |
| Regular Season: Week 15 |
 Eagles |
at |
Chargers |
Sunday, December 15, 1985 |
3:00PM |
PHI 14, SD 20 |
| Regular Season: Week 16 |
Chargers |
at |
Chiefs |
Sunday, December 22, 1985 |
3:00PM |
SD 34, KC 38 |