| Regular Season: Week 1 |
 Chargers |
at |
 Chiefs |
Sunday, September 13, 1987 |
3:00PM |
SD 13, KC 20 |
| Regular Season: Week 2 |
 Cardinals |
at |
Chargers |
Sunday, September 20, 1987 |
3:00PM |
STL 24, SD 28 |
| Regular Season: Week 3 |
Chargers |
at |
 Bengals |
Sunday, October 4, 1987 |
3:00PM |
SD 10, CIN 9 |
| Regular Season: Week 4 |
Chargers |
at |
 Buccaneers |
Sunday, October 11, 1987 |
3:00PM |
SD 17, TB 13 |
| Regular Season: Week 5 |
Chargers |
at |
 Raiders |
Sunday, October 18, 1987 |
3:00PM |
SD 23, RAI 17 |
| Regular Season: Week 6 |
Chiefs |
at |
Chargers |
Sunday, October 25, 1987 |
2:00PM |
KC 21, SD 42 |
| Regular Season: Week 7 |
 Browns |
at |
Chargers |
Sunday, November 1, 1987 |
3:00PM |
CLE 24, SD 27 |
| Regular Season: Week 8 |
Chargers |
at |
 Colts |
Sunday, November 8, 1987 |
3:00PM |
SD 16, IND 13 |
| Regular Season: Week 9 |
Raiders |
at |
Chargers |
Sunday, November 15, 1987 |
3:00PM |
RAI 14, SD 16 |
| Regular Season: Week 10 |
Chargers |
at |
 Seahawks |
Sunday, November 22, 1987 |
3:00PM |
SD 3, SEA 34 |
| Regular Season: Week 11 |
 Broncos |
at |
Chargers |
Sunday, November 29, 1987 |
3:00PM |
DEN 31, SD 17 |
| Regular Season: Week 12 |
Chargers |
at |
 Oilers |
Sunday, December 6, 1987 |
3:00PM |
SD 18, HOU 33 |
| Regular Season: Week 13 |
 Steelers |
at |
Chargers |
Sunday, December 13, 1987 |
3:00PM |
PIT 20, SD 16 |
| Regular Season: Week 14 |
Colts |
at |
Chargers |
Sunday, December 20, 1987 |
3:00PM |
IND 20, SD 7 |
| Regular Season: Week 15 |
Chargers |
at |
Broncos |
Sunday, December 27, 1987 |
3:00PM |
SD 0, DEN 24 |