| Regular Season: Week 1 |
 Chargers |
at |
 Raiders |
Sunday, September 4, 1988 |
3:00PM |
SD 13, RAI 24 |
| Regular Season: Week 2 |
Chargers |
at |
 Broncos |
Sunday, September 11, 1988 |
3:00PM |
SD 3, DEN 34 |
| Regular Season: Week 3 |
 Seahawks |
at |
Chargers |
Sunday, September 18, 1988 |
3:00PM |
SEA 6, SD 17 |
| Regular Season: Week 4 |
Chargers |
at |
 Chiefs |
Sunday, September 25, 1988 |
3:00PM |
SD 24, KC 23 |
| Regular Season: Week 5 |
Broncos |
at |
Chargers |
Sunday, October 2, 1988 |
3:00PM |
DEN 12, SD 0 |
| Regular Season: Week 6 |
 Saints |
at |
Chargers |
Sunday, October 9, 1988 |
3:00PM |
NO 23, SD 17 |
| Regular Season: Week 7 |
Chargers |
at |
 Dolphins |
Sunday, October 16, 1988 |
3:00PM |
SD 28, MIA 31 |
| Regular Season: Week 8 |
 Colts |
at |
Chargers |
Sunday, October 23, 1988 |
3:00PM |
IND 16, SD 0 |
| Regular Season: Week 9 |
Chargers |
at |
Seahawks |
Sunday, October 30, 1988 |
2:00PM |
SD 14, SEA 17 |
| Regular Season: Week 10 |
Raiders |
at |
Chargers |
Sunday, November 6, 1988 |
3:00PM |
RAI 13, SD 3 |
| Regular Season: Week 11 |
Chargers |
at |
 Falcons |
Sunday, November 13, 1988 |
3:00PM |
SD 10, ATL 7 |
| Regular Season: Week 12 |
Chargers |
at |
 Rams |
Sunday, November 20, 1988 |
3:00PM |
SD 38, RAM 24 |
| Regular Season: Week 13 |
 49ers |
at |
Chargers |
Sunday, November 27, 1988 |
3:00PM |
SF 48, SD 10 |
| Regular Season: Week 14 |
Chargers |
at |
 Bengals |
Sunday, December 4, 1988 |
3:00PM |
SD 10, CIN 27 |
| Regular Season: Week 15 |
 Steelers |
at |
Chargers |
Sunday, December 11, 1988 |
3:00PM |
PIT 14, SD 20 |
| Regular Season: Week 16 |
Chiefs |
at |
Chargers |
Sunday, December 18, 1988 |
3:00PM |
KC 13, SD 24 |