| Regular Season: Week 1 |
 Chargers |
at |
 Cowboys |
Sunday, September 9, 1990 |
3:00PM |
SD 14, DAL 17 |
| Regular Season: Week 2 |
 Bengals |
at |
Chargers |
Sunday, September 16, 1990 |
3:00PM |
CIN 21, SD 16 |
| Regular Season: Week 3 |
Chargers |
at |
 Browns |
Sunday, September 23, 1990 |
3:00PM |
SD 24, CLE 14 |
| Regular Season: Week 4 |
 Oilers |
at |
Chargers |
Sunday, September 30, 1990 |
3:00PM |
HOU 17, SD 7 |
| Regular Season: Week 5 |
Chargers |
at |
 Steelers |
Sunday, October 7, 1990 |
3:00PM |
SD 14, PIT 36 |
| Regular Season: Week 6 |
Chargers |
at |
 Jets |
Sunday, October 14, 1990 |
3:00PM |
SD 39, NYJ 3 |
| Regular Season: Week 7 |
 Raiders |
at |
Chargers |
Sunday, October 21, 1990 |
3:00PM |
RAI 24, SD 9 |
| Regular Season: Week 8 |
 Buccaneers |
at |
Chargers |
Sunday, October 28, 1990 |
2:00PM |
TB 10, SD 41 |
| Regular Season: Week 9 |
Chargers |
at |
 Seahawks |
Sunday, November 4, 1990 |
3:00PM |
SD 31, SEA 14 |
| Regular Season: Week 10 |
 Broncos |
at |
Chargers |
Sunday, November 11, 1990 |
3:00PM |
DEN 7, SD 19 |
| Regular Season: Week 11 |
Chargers |
at |
 Chiefs |
Sunday, November 18, 1990 |
3:00PM |
SD 10, KC 27 |
| Regular Season: Week 12 |
Seahawks |
at |
Chargers |
Sunday, November 25, 1990 |
3:00PM |
SEA 13, SD 10 |
| Regular Season: Week 13 |
Jets |
at |
Chargers |
Sunday, December 2, 1990 |
3:00PM |
NYJ 17, SD 38 |
| Regular Season: Week 15 |
Chargers |
at |
Broncos |
Sunday, December 16, 1990 |
3:00PM |
SD 10, DEN 20 |
| Regular Season: Week 16 |
Chiefs |
at |
Chargers |
Sunday, December 23, 1990 |
3:00PM |
KC 24, SD 21 |
| Regular Season: Week 17 |
Chargers |
at |
Raiders |
Sunday, December 30, 1990 |
3:00PM |
SD 12, RAI 17 |