| Regular Season: Week 1 |
 Chargers |
at |
 Steelers |
Sunday, September 1, 1991 |
3:00PM |
SD 20, PIT 26 |
| Regular Season: Week 2 |
Chargers |
at |
 49ers |
Sunday, September 8, 1991 |
3:00PM |
SD 14, SF 34 |
| Regular Season: Week 3 |
 Falcons |
at |
Chargers |
Sunday, September 15, 1991 |
3:00PM |
ATL 13, SD 10 |
| Regular Season: Week 4 |
Chargers |
at |
 Broncos |
Sunday, September 22, 1991 |
3:00PM |
SD 19, DEN 27 |
| Regular Season: Week 5 |
 Chiefs |
at |
Chargers |
Sunday, September 29, 1991 |
3:00PM |
KC 14, SD 13 |
| Regular Season: Week 6 |
Chargers |
at |
 Raiders |
Sunday, October 6, 1991 |
3:00PM |
SD 21, RAI 13 |
| Regular Season: Week 7 |
Chargers |
at |
 Rams |
Sunday, October 13, 1991 |
3:00PM |
SD 24, RAM 30 |
| Regular Season: Week 8 |
 Browns |
at |
Chargers |
Sunday, October 20, 1991 |
3:00PM |
CLE 30, SD 24 |
| Regular Season: Week 9 |
Chargers |
at |
 Seahawks |
Sunday, October 27, 1991 |
2:00PM |
SD 9, SEA 20 |
| Regular Season: Week 11 |
Seahawks |
at |
Chargers |
Sunday, November 10, 1991 |
3:00PM |
SEA 14, SD 17 |
| Regular Season: Week 12 |
 Saints |
at |
Chargers |
Sunday, November 17, 1991 |
3:00PM |
NO 21, SD 24 |
| Regular Season: Week 13 |
Chargers |
at |
 Jets |
Sunday, November 24, 1991 |
3:00PM |
SD 3, NYJ 24 |
| Regular Season: Week 14 |
Raiders |
at |
Chargers |
Sunday, December 1, 1991 |
3:00PM |
RAI 9, SD 7 |
| Regular Season: Week 15 |
Chargers |
at |
Chiefs |
Sunday, December 8, 1991 |
3:00PM |
SD 17, KC 20 |
| Regular Season: Week 16 |
 Dolphins |
at |
Chargers |
Sunday, December 15, 1991 |
3:00PM |
MIA 30, SD 38 |
| Regular Season: Week 17 |
Broncos |
at |
Chargers |
Sunday, December 22, 1991 |
3:00PM |
DEN 17, SD 14 |