| Regular Season: Week 1 |
 Chargers |
at |
 Raiders |
Sunday, September 3, 2000 |
4:15PM |
SD 6, OAK 9 |
| Regular Season: Week 2 |
 Saints |
at |
Chargers |
Sunday, September 10, 2000 |
4:15PM |
NO 28, SD 27 |
| Regular Season: Week 3 |
Chargers |
at |
 Chiefs |
Sunday, September 17, 2000 |
1:00PM |
SD 10, KC 42 |
| Regular Season: Week 4 |
 Seahawks |
at |
Chargers |
Sunday, September 24, 2000 |
4:15PM |
SEA 20, SD 12 |
| Regular Season: Week 5 |
Chargers |
at |
 Rams |
Sunday, October 1, 2000 |
1:00PM |
SD 31, STL 57 |
| Regular Season: Week 6 |
 Broncos |
at |
Chargers |
Sunday, October 8, 2000 |
4:15PM |
DEN 21, SD 7 |
| Regular Season: Week 7 |
Chargers |
at |
 Bills |
Sunday, October 15, 2000 |
1:00PM |
SD 24, BUF 27 |
| Regular Season: Week 9 |
Raiders |
at |
Chargers |
Sunday, October 29, 2000 |
8:20PM |
OAK 15, SD 13 |
| Regular Season: Week 10 |
Chargers |
at |
Seahawks |
Sunday, November 5, 2000 |
4:15PM |
SD 15, SEA 17 |
| Regular Season: Week 11 |
 Dolphins |
at |
Chargers |
Sunday, November 12, 2000 |
4:05PM |
MIA 17, SD 7 |
| Regular Season: Week 12 |
Chargers |
at |
Broncos |
Sunday, November 19, 2000 |
4:05PM |
SD 37, DEN 38 |
| Regular Season: Week 13 |
Chiefs |
at |
Chargers |
Sunday, November 26, 2000 |
4:15PM |
KC 16, SD 17 |
| Regular Season: Week 14 |
 49ers |
at |
Chargers |
Sunday, December 3, 2000 |
4:05PM |
SF 45, SD 17 |
| Regular Season: Week 15 |
Chargers |
at |
 Ravens |
Sunday, December 10, 2000 |
1:00PM |
SD 3, BAL 24 |
| Regular Season: Week 16 |
Chargers |
at |
 Panthers |
Sunday, December 17, 2000 |
1:00PM |
SD 22, CAR 30 |
| Regular Season: Week 17 |
 Steelers |
at |
Chargers |
Sunday, December 24, 2000 |
4:05PM |
PIT 34, SD 21 |