| Regular Season: Week 1 |
 Cowboys |
at |
 Chargers |
Sunday, September 11, 2005 |
4:15PM |
DAL 28, SD 24 |
| Regular Season: Week 2 |
Chargers |
at |
 Broncos |
Sunday, September 18, 2005 |
4:15PM |
SD 17, DEN 20 |
| Regular Season: Week 3 |
 Giants |
at |
Chargers |
Sunday, September 25, 2005 |
8:30PM |
NYG 23, SD 45 |
| Regular Season: Week 4 |
Chargers |
at |
 Patriots |
Sunday, October 2, 2005 |
1:00PM |
SD 41, NE 17 |
| Regular Season: Week 5 |
 Steelers |
at |
Chargers |
Monday, October 10, 2005 |
9:00PM |
PIT 24, SD 22 |
| Regular Season: Week 6 |
Chargers |
at |
 Raiders |
Sunday, October 16, 2005 |
4:15PM |
SD 27, OAK 14 |
| Regular Season: Week 7 |
Chargers |
at |
 Eagles |
Sunday, October 23, 2005 |
1:00PM |
SD 17, PHI 20 |
| Regular Season: Week 8 |
 Chiefs |
at |
Chargers |
Sunday, October 30, 2005 |
4:05PM |
KC 20, SD 28 |
| Regular Season: Week 9 |
Chargers |
at |
 Jets |
Sunday, November 6, 2005 |
1:00PM |
SD 31, NYJ 26 |
| Regular Season: Week 11 |
 Bills |
at |
Chargers |
Sunday, November 20, 2005 |
4:15PM |
BUF 10, SD 48 |
| Regular Season: Week 12 |
Chargers |
at |
 Redskins |
Sunday, November 27, 2005 |
1:00PM |
SD 23, WAS 17 |
| Regular Season: Week 13 |
Raiders |
at |
Chargers |
Sunday, December 4, 2005 |
8:30PM |
OAK 10, SD 34 |
| Regular Season: Week 14 |
 Dolphins |
at |
Chargers |
Sunday, December 11, 2005 |
4:15PM |
MIA 23, SD 21 |
| Regular Season: Week 15 |
Chargers |
at |
 Colts |
Sunday, December 18, 2005 |
1:00PM |
SD 26, IND 17 |
| Regular Season: Week 16 |
Chargers |
at |
Chiefs |
Saturday, December 24, 2005 |
1:00PM |
SD 7, KC 20 |
| Regular Season: Week 17 |
Broncos |
at |
Chargers |
Saturday, December 31, 2005 |
4:30PM |
DEN 23, SD 7 |