| Regular Season: Week 1 |
 Panthers |
at |
 Chargers |
Sunday, September 7, 2008 |
4:15PM |
CAR 26, SD 24 |
| Regular Season: Week 2 |
Chargers |
at |
 Broncos |
Sunday, September 14, 2008 |
4:15PM |
SD 38, DEN 39 |
| Regular Season: Week 3 |
 Jets |
at |
Chargers |
Monday, September 22, 2008 |
8:30PM |
NYJ 29, SD 48 |
| Regular Season: Week 4 |
Chargers |
at |
 Raiders |
Sunday, September 28, 2008 |
4:05PM |
SD 28, OAK 18 |
| Regular Season: Week 5 |
Chargers |
at |
 Dolphins |
Sunday, October 5, 2008 |
1:00PM |
SD 10, MIA 17 |
| Regular Season: Week 6 |
 Patriots |
at |
Chargers |
Sunday, October 12, 2008 |
8:15PM |
NE 10, SD 30 |
| Regular Season: Week 7 |
Chargers |
at |
 Bills |
Sunday, October 19, 2008 |
1:00PM |
SD 14, BUF 23 |
| Regular Season: Week 8 |
Chargers |
at |
 Saints |
Sunday, October 26, 2008 |
1:00PM |
SD 32, NO 37 |
| Regular Season: Week 10 |
 Chiefs |
at |
Chargers |
Sunday, November 9, 2008 |
4:15PM |
KC 19, SD 20 |
| Regular Season: Week 11 |
Chargers |
at |
 Steelers |
Sunday, November 16, 2008 |
4:15PM |
SD 10, PIT 11 |
| Regular Season: Week 12 |
 Colts |
at |
Chargers |
Sunday, November 23, 2008 |
8:15PM |
IND 23, SD 20 |
| Regular Season: Week 13 |
 Falcons |
at |
Chargers |
Sunday, November 30, 2008 |
4:05PM |
ATL 22, SD 16 |
| Regular Season: Week 14 |
Raiders |
at |
Chargers |
Thursday, December 4, 2008 |
8:15PM |
OAK 7, SD 34 |
| Regular Season: Week 15 |
Chargers |
at |
Chiefs |
Sunday, December 14, 2008 |
1:00PM |
SD 22, KC 21 |
| Regular Season: Week 16 |
Chargers |
at |
 Buccaneers |
Sunday, December 21, 2008 |
1:00PM |
SD 41, TB 24 |
| Regular Season: Week 17 |
Broncos |
at |
Chargers |
Sunday, December 28, 2008 |
8:15PM |
DEN 21, SD 52 |
| Wild Card: Week 18 |
Colts |
at |
Chargers |
Saturday, January 3, 2009 |
8:00PM |
IND 17, SD 23 |
| Divisional Playoffs: Week 19 |
Chargers |
at |
Steelers |
Sunday, January 11, 2009 |
4:45PM |
SD 24, PIT 35 |