| Regular Season: Week 1 |
 Chargers |
at |
 Chiefs |
Sunday, September 11, 2016 |
1:00PM |
SD 27, KC 33 |
| Regular Season: Week 2 |
 Jaguars |
at |
Chargers |
Sunday, September 18, 2016 |
4:25PM |
JAX 14, SD 38 |
| Regular Season: Week 3 |
Chargers |
at |
 Colts |
Sunday, September 25, 2016 |
4:25PM |
SD 22, IND 26 |
| Regular Season: Week 4 |
 Saints |
at |
Chargers |
Sunday, October 2, 2016 |
4:25PM |
NO 35, SD 34 |
| Regular Season: Week 5 |
Chargers |
at |
 Raiders |
Sunday, October 9, 2016 |
4:25PM |
SD 31, OAK 34 |
| Regular Season: Week 6 |
 Broncos |
at |
Chargers |
Thursday, October 13, 2016 |
8:25PM |
DEN 13, SD 21 |
| Regular Season: Week 7 |
Chargers |
at |
 Falcons |
Sunday, October 23, 2016 |
4:05PM |
SD 33, ATL 30 |
| Regular Season: Week 8 |
Chargers |
at |
Broncos |
Sunday, October 30, 2016 |
4:05PM |
SD 19, DEN 27 |
| Regular Season: Week 9 |
 Titans |
at |
Chargers |
Sunday, November 6, 2016 |
4:25PM |
TEN 35, SD 43 |
| Regular Season: Week 10 |
 Dolphins |
at |
Chargers |
Sunday, November 13, 2016 |
4:05PM |
MIA 31, SD 24 |
| Regular Season: Week 12 |
Chargers |
at |
 Texans |
Sunday, November 27, 2016 |
1:00PM |
SD 21, HOU 13 |
| Regular Season: Week 13 |
 Buccaneers |
at |
Chargers |
Sunday, December 4, 2016 |
4:25PM |
TB 28, SD 21 |
| Regular Season: Week 14 |
Chargers |
at |
 Panthers |
Sunday, December 11, 2016 |
1:00PM |
SD 16, CAR 28 |
| Regular Season: Week 15 |
Raiders |
at |
Chargers |
Sunday, December 18, 2016 |
4:25PM |
OAK 19, SD 16 |
| Regular Season: Week 16 |
Chargers |
at |
 Browns |
Saturday, December 24, 2016 |
1:00PM |
SD 17, CLE 20 |
| Regular Season: Week 17 |
Chiefs |
at |
Chargers |
Sunday, January 1, 2017 |
4:25PM |
KC 37, SD 27 |