| Regular Season: Week 1 |
 Chiefs |
at |
 Bengals |
Sunday, September 3, 1978 |
3:00PM |
KC 24, CIN 23 |
| Regular Season: Week 2 |
 Oilers |
at |
Chiefs |
Sunday, September 10, 1978 |
3:00PM |
HOU 20, KC 17 |
| Regular Season: Week 3 |
Chiefs |
at |
 Giants |
Sunday, September 17, 1978 |
3:00PM |
KC 10, NYG 26 |
| Regular Season: Week 4 |
 Broncos |
at |
Chiefs |
Sunday, September 24, 1978 |
3:00PM |
DEN 23, KC 17 |
| Regular Season: Week 5 |
Chiefs |
at |
 Bills |
Sunday, October 1, 1978 |
3:00PM |
KC 13, BUF 28 |
| Regular Season: Week 6 |
 Buccaneers |
at |
Chiefs |
Sunday, October 8, 1978 |
3:00PM |
TB 30, KC 13 |
| Regular Season: Week 7 |
Chiefs |
at |
 Raiders |
Sunday, October 15, 1978 |
3:00PM |
KC 6, OAK 28 |
| Regular Season: Week 8 |
 Browns |
at |
Chiefs |
Sunday, October 22, 1978 |
3:00PM |
CLE 3, KC 17 |
| Regular Season: Week 9 |
Chiefs |
at |
 Steelers |
Sunday, October 29, 1978 |
2:00PM |
KC 24, PIT 27 |
| Regular Season: Week 10 |
Raiders |
at |
Chiefs |
Sunday, November 5, 1978 |
3:00PM |
OAK 20, KC 10 |
| Regular Season: Week 11 |
Chiefs |
at |
 Chargers |
Sunday, November 12, 1978 |
3:00PM |
KC 23, SD 29 |
| Regular Season: Week 12 |
 Seahawks |
at |
Chiefs |
Sunday, November 19, 1978 |
3:00PM |
SEA 13, KC 10 |
| Regular Season: Week 13 |
Chargers |
at |
Chiefs |
Sunday, November 26, 1978 |
3:00PM |
SD 0, KC 23 |
| Regular Season: Week 14 |
Bills |
at |
Chiefs |
Sunday, December 3, 1978 |
3:00PM |
BUF 10, KC 14 |
| Regular Season: Week 15 |
Chiefs |
at |
Broncos |
Sunday, December 10, 1978 |
3:00PM |
KC 3, DEN 24 |
| Regular Season: Week 16 |
Chiefs |
at |
Seahawks |
Sunday, December 17, 1978 |
3:00PM |
KC 19, SEA 23 |