| Regular Season: Week 1 |
 Raiders |
at |
 Chiefs |
Sunday, September 7, 1980 |
3:00PM |
OAK 27, KC 14 |
| Regular Season: Week 2 |
 Seahawks |
at |
Chiefs |
Sunday, September 14, 1980 |
3:00PM |
SEA 17, KC 16 |
| Regular Season: Week 3 |
Chiefs |
at |
 Browns |
Sunday, September 21, 1980 |
3:00PM |
KC 13, CLE 20 |
| Regular Season: Week 4 |
 Chargers |
at |
Chiefs |
Sunday, September 28, 1980 |
3:00PM |
SD 24, KC 7 |
| Regular Season: Week 5 |
Chiefs |
at |
Raiders |
Sunday, October 5, 1980 |
3:00PM |
KC 31, OAK 17 |
| Regular Season: Week 6 |
 Oilers |
at |
Chiefs |
Sunday, October 12, 1980 |
3:00PM |
HOU 20, KC 21 |
| Regular Season: Week 7 |
Chiefs |
at |
 Broncos |
Sunday, October 19, 1980 |
3:00PM |
KC 23, DEN 17 |
| Regular Season: Week 8 |
 Lions |
at |
Chiefs |
Sunday, October 26, 1980 |
2:00PM |
DET 17, KC 20 |
| Regular Season: Week 9 |
 Colts |
at |
Chiefs |
Sunday, November 2, 1980 |
3:00PM |
BAL 31, KC 24 |
| Regular Season: Week 10 |
Chiefs |
at |
Seahawks |
Sunday, November 9, 1980 |
3:00PM |
KC 31, SEA 30 |
| Regular Season: Week 11 |
Chiefs |
at |
Chargers |
Sunday, November 16, 1980 |
3:00PM |
KC 7, SD 20 |
| Regular Season: Week 12 |
Chiefs |
at |
 Cardinals |
Sunday, November 23, 1980 |
3:00PM |
KC 21, STL 13 |
| Regular Season: Week 13 |
 Bengals |
at |
Chiefs |
Sunday, November 30, 1980 |
3:00PM |
CIN 20, KC 6 |
| Regular Season: Week 14 |
Broncos |
at |
Chiefs |
Sunday, December 7, 1980 |
3:00PM |
DEN 14, KC 31 |
| Regular Season: Week 15 |
Chiefs |
at |
 Steelers |
Sunday, December 14, 1980 |
3:00PM |
KC 16, PIT 21 |
| Regular Season: Week 16 |
Chiefs |
at |
Colts |
Sunday, December 21, 1980 |
3:00PM |
KC 38, BAL 28 |