| Regular Season: Week 1 |
 Chiefs |
at |
 Steelers |
Sunday, September 6, 1981 |
3:00PM |
KC 37, PIT 33 |
| Regular Season: Week 2 |
 Buccaneers |
at |
Chiefs |
Sunday, September 13, 1981 |
3:00PM |
TB 10, KC 19 |
| Regular Season: Week 3 |
 Chargers |
at |
Chiefs |
Sunday, September 20, 1981 |
3:00PM |
SD 42, KC 31 |
| Regular Season: Week 4 |
Chiefs |
at |
 Seahawks |
Sunday, September 27, 1981 |
3:00PM |
KC 20, SEA 14 |
| Regular Season: Week 5 |
Chiefs |
at |
 Patriots |
Sunday, October 4, 1981 |
3:00PM |
KC 17, NE 33 |
| Regular Season: Week 6 |
 Raiders |
at |
Chiefs |
Sunday, October 11, 1981 |
3:00PM |
OAK 0, KC 27 |
| Regular Season: Week 7 |
 Broncos |
at |
Chiefs |
Sunday, October 18, 1981 |
3:00PM |
DEN 14, KC 28 |
| Regular Season: Week 8 |
Chiefs |
at |
Raiders |
Sunday, October 25, 1981 |
2:00PM |
KC 28, OAK 17 |
| Regular Season: Week 9 |
Chiefs |
at |
Chargers |
Sunday, November 1, 1981 |
3:00PM |
KC 20, SD 22 |
| Regular Season: Week 10 |
 Bears |
at |
Chiefs |
Sunday, November 8, 1981 |
3:00PM |
CHI 16, KC 13 |
| Regular Season: Week 11 |
 Oilers |
at |
Chiefs |
Sunday, November 15, 1981 |
3:00PM |
HOU 10, KC 23 |
| Regular Season: Week 12 |
Seahawks |
at |
Chiefs |
Sunday, November 22, 1981 |
3:00PM |
SEA 13, KC 40 |
| Regular Season: Week 13 |
Chiefs |
at |
 Lions |
Thursday, November 26, 1981 |
3:00PM |
KC 10, DET 27 |
| Regular Season: Week 14 |
Chiefs |
at |
Broncos |
Sunday, December 6, 1981 |
3:00PM |
KC 13, DEN 16 |
| Regular Season: Week 15 |
 Dolphins |
at |
Chiefs |
Sunday, December 13, 1981 |
3:00PM |
MIA 17, KC 7 |
| Regular Season: Week 16 |
Chiefs |
at |
 Vikings |
Sunday, December 20, 1981 |
3:00PM |
KC 10, MIN 6 |